지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 371 - 377 (7page)
- DOI
- 10.9799/ksfan.2017.30.2.371
이용수
초록· 키워드
오류제보하기
Muscle atrophy is characterized by a decrease in the mass of the muscle. With an increase in life expectancy and chronic illnesses, the incidence of muscle atrophy is increasing and the quality of life of patients is decreasing. Thus, reducing muscle atrophy is of high clinical and socio-economic importance. Mistletoe is a semi-parasitic plant that has been used as a traditional medicine in many countries to treat various human illnesses. It has been reported that Korean mistletoe extract (KME) has diverse biological functions including anti-tumor, anti-oxidant, anti-diabetic, anti-obesity properties, and extension of lifespan. Especially, we have recently reported that KME improves exercise endurance in mice, indicating its beneficial roles in enhancing the capacity of skeletal muscle. In this study, we investigated whether KME could activate the signaling pathway related to protein synthesis in a mouse model of muscle atrophy. Interestingly, KME efficiently activated the Akt/mTOR pathway, and Akt and mTOR are important signaling hub molecules for the acceleration of protein synthesis in muscle cells. In addition, KME also increased the activity of S6 kinase which is involved in the regulation of muscle cell size. Moreover, the ERK activity, required for transcription of ribosomal RNA for protein synthesis, was also enhanced in KME-treated mouse muscle. These data support the idea that KME increases muscle mass via increased protein synthesis. Our findings also suggest that Korean mistletoe might be a promising candidate for the development of functional foods that are beneficial for preventing muscle atrophy.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Arvisais EW / 2006 / AKTindependent phosphorylation of TSC2 and activation of mTOR and ribosomal protein S6 kinase signaling by prostaglandin F2alpha / J Biol Chem 281:26904~26913
Bianchi L / 2016 / Muscle dysfunction in type 2 diabetes : a major threat to patient's mobility and independence / Acta Diabetol 53:1~11
Cohen S / 2015 / Muscle wasting in disease : molecular mechanisms and promising therapies / Nat Rev Drug Discov 14:58~74
Cruz-Jentoft AJ / 2010 / Understanding sarcopenia as a geriatric syndrome / Curr Opin Clin Nutr Metab Care 13:1~7
Ehrenborg E / 2009 / Regulation of skeletal muscle physiology and metabolism by peroxisome proliferatoractivated receptor delta / Pharmacol Rev 61:373~393
Bianchi L / 2016 / Muscle dysfunction in type 2 diabetes : a major threat to patient's mobility and independence / Acta Diabetol 53:1~11
Cohen S / 2015 / Muscle wasting in disease : molecular mechanisms and promising therapies / Nat Rev Drug Discov 14:58~74
Cruz-Jentoft AJ / 2010 / Understanding sarcopenia as a geriatric syndrome / Curr Opin Clin Nutr Metab Care 13:1~7
Ehrenborg E / 2009 / Regulation of skeletal muscle physiology and metabolism by peroxisome proliferatoractivated receptor delta / Pharmacol Rev 61:373~393
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