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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 1,364 - 1,369 (6page)
- DOI
- 10.9799/ksfan.2017.30.6.1364
이용수
초록· 키워드
오류제보하기
There is a growing demand for natural sleep aids due to various side effects of long-term administration of pharmacological treatments for insomnia. Honey has been reported to exhibit numerous potential health benefits, and it is hypothesized that honey may favorably affect insomnia treatment. Therefore, this study was performed to investigate the possible hypnotic effect of clover honey (CH) and to determine its in vivo mechanism. The total flavonoid content (TFC) of CH and fractions extracted with ethylacetate (EtOAc) and H2O was measured. The pentobarbital-induced sleep test using GABAA-benzodiazepine (BZD) agonists and antagonists was conducted to evaluate the potential mechanism of action behind the sedative-hypnotic activity of CH in mice. The results showed that administration of 500 and 1,000 mg/kg of CH significantly (p<0.01) reduced the sleep latency to a level similar to that of diazepam (DZP, 2 mg/kg), and 1,000 mg/kg of CH significantly (p<0.01) prolonged the sleep duration, which was comparable to that of DZP (2 mg/kg). Administration of the EtOAc fraction with a higher TFC significantly reduced the sleep latency at 50 to 200 mg/kg and prolonged the sleep duration at 100 to 200 mg/kg, which were comparable to those after administration of DZP (2 mg/kg). However, co-administration of CH and EtOAc with flumazenil, a specific GABAA-BZD receptor antagonist, blocked the hypnotic effect. Our findings suggest that the hypnotic activity of CH may be attributed to allosteric modulation of GABAA-BZD receptors. The TFC of CH is expected to be a key factor that contributes to its hypnotic effect.
Key words: clover honey, flavonoid, hypnotic activity, insomnia, GABAA-BZD receptor
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Ahmed S / 2013 / Review of the medicinal effects of tualang honey and a comparison with Manuka honey / Malays J Med Sci 20:6~13
Akanmu MA / 2011 / Neuropharmacological effects of Nigerian honey in mice / Afr J Tradit Complement Altern Med 8:230~249
Al-Mamary M / 2002 / Antioxidant activities and total phenolics of different types of honey / Nutr Res 22:1041~1047
Atanda MA / 2011 / Neuropharmacological effects of Nigerian honey in mice / Afr J Tradit Complement Altern Med 8:230~249
Bilsel Y / 2002 / Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation / Dig Surg 29:306~312
Akanmu MA / 2011 / Neuropharmacological effects of Nigerian honey in mice / Afr J Tradit Complement Altern Med 8:230~249
Al-Mamary M / 2002 / Antioxidant activities and total phenolics of different types of honey / Nutr Res 22:1041~1047
Atanda MA / 2011 / Neuropharmacological effects of Nigerian honey in mice / Afr J Tradit Complement Altern Med 8:230~249
Bilsel Y / 2002 / Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation / Dig Surg 29:306~312
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