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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 150 - 157 (8page)
- DOI
- 10.1186/s40824-018-0127-9
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초록· 키워드
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Background: Gadolinium-based contrast agents are widely used as a contrast agent for magnetic resonance imaging. Since gadolinium ions are toxic, many chelators are developed to bind gadolinium ions to prevent free gadolinium-associated disease. However, many reports indicated that linear chelator-based contrast agents are associated with nephrogenic systemic fibrosis (NSF) in patients with low kidney function. Therefore, the demand for stable macrocyclic chelator-based contrast agent is now increasing. Method: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA) was conjugated to lactobionic acid (LBA) through DCC-NHS coupling reaction. Gd3+ (gadolinium ion) was chelated to 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate-lactobionic acid (DOTA-LAE) and free Gd3+ was removed using a cation exchange column. In vitro cytotoxicity of contrast agent towards normal cells was measured using MTT assay. For in vivo MR imaging, contrast agents were intravenously injected to tumor-bearing mice and imaged by a MR imaging scanner. Results: This new macrocyclic gadolinium-based contrast agent showed enhanced in vitro paramagnetic properties compared to Gadovist. In addition, Gd-DOTA-LAE showed a 29% increased contrast enhancement of tumor tissue compared to normal tissue within 20 min past IV injection. Conclusions: We developed a new macrocyclic T1-weighted MR contrast agent. This new contrast agent offers various opportunities for cancer detection and diagnosis.
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참고문헌 (25)
참고문헌 신청
Jaffer FA / 2005 / Molecular imaging in the clinical arena / JAMA 293:855~862
Koh D-M / 2003 / New horizons in oncologic imaging / N Engl J Med 348:2487~2488
Caravan P / 1999 / Gadolinium (III) chelates as MRI contrast agents: structure, dynamics, and applications / Chem Rev 99:2293~2352
Li Y / 2012 / Macromolecular ligands for gadolinium MRI contrast agents / Macromolecules 45:4196~4204
Lim J / 2012 / Gadolinium MRI contrast agents based on triazine dendrimers: relaxivity and in vivo pharmacokinetics / Bioconjug Chem 23:2291~2299
Koh D-M / 2003 / New horizons in oncologic imaging / N Engl J Med 348:2487~2488
Caravan P / 1999 / Gadolinium (III) chelates as MRI contrast agents: structure, dynamics, and applications / Chem Rev 99:2293~2352
Li Y / 2012 / Macromolecular ligands for gadolinium MRI contrast agents / Macromolecules 45:4196~4204
Lim J / 2012 / Gadolinium MRI contrast agents based on triazine dendrimers: relaxivity and in vivo pharmacokinetics / Bioconjug Chem 23:2291~2299
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