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논문 기본 정보

자료유형
학술저널
저자정보
Ee-Seul Kang (Chung-Ang University) Da-Seul Kim (Chung-Ang University) Intan Rosalina Suhito (Chung-Ang University) Wanhee Lee (Chung-Ang University) Inbeom Song (Chung-Ang University) Tae-HyungKim (Chung-Ang University)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제22권 제2호
발행연도
2018.6
수록면
85 - 96 (12page)
DOI
10.1186/s40824-018-0120-3

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Background: In the past decade, stem cells, with their ability to differentiate into various types of cells, have been proven to be resourceful in regenerative medicine and tissue engineering. Despite the ability to repair damaged parts of organs and tissues, the use of stem cells still entails several limitations, such as low differentiation efficiency and difficulties in guiding differentiation. To address these limitations, nanotechnology approaches have been recently implemented in stem cell research. It has been discovered that stem cells, in combination with carbon-based functional materials, show enhanced regenerative performances in varying biophysical conditions. In particular, several studies have reported solutions to the conventional quandaries in biomedical engineering, using synergetic effects of nanohybrid materials, as well as further development of technologies to recover from diverse health conditions such as bone fracture and strokes. Main text: In this review, we discuss several prior studies regarding the application of various nanomaterials in controlling the behavior of stem cells. We focus on the potential of different types of nanomaterials, such as two-dimensional materials, gold nanoparticles, and three-dimensional nanohybrid composites, to control the differentiation of human mesenchymal stem cells (hMSCs). These materials have been found to affect stem cell functions via the adsorption of growth/differentiation factors on the surfaces of nanomaterials and the activation of signaling pathways that are mostly related to cell adhesion and differentiation (e.g., FAK, Smad, Erk, and Wnt). Conclusion: Controlling stem cell differentiation using biophysical factors, especially the use of nanohybrid materials to functionalize underlying substrates wherein the cells attach and grow, is a promising strategy to achieve cells of interest in a highly efficient manner. We hope that this review will facilitate the use of other types of newly discovered and/or synthesized nanomaterials (e.g., metal transition dichalcogenides, non-toxic quantum dots, and metal oxide frameworks) for stem cell-based regenerative therapies.
#Graphene #Two-dimensional materials #Gold nanoparticles #Three-dimensional graphene composites #Human mesenchymal stem cell #Differentiation

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참고문헌 (102)

참고문헌 신청
Kim YJ / 2009 / MiR-21 regulates Adipogenic differentiation through the modulation of TGF-${\beta}$ signaling in mesenchymal stem cells derived from human adipose tissue / Stem Cells 27:3093~3102 google schola zur Nieden NI / 2005 / Induction of chondro-, osteoand adipogenesis in embryonic stem cells by bone morphogenetic protein-2: effect of cofactors on differentiating lineages / BMC Dev Biol 5:1 Crossref Derfoul A / 2006 / Glucocorticoids promote Chondrogenic differentiation of adult human mesenchymal stem cells by enhancing expression of cartilage extracellular matrix genes / Stem Cells 24:1487~1495 Crossref Lee WC / 2011 / Origin of enhanced stem cell growth and differentiation on graphene and graphene oxide / ACS Nano 5:7334~7341 Crossref Christopherson GT / 2009 / The influence of fiber diameter of electrospun substrates on neural stem cell differentiation and proliferation / Biomaterials 30:556~564 Crossref

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