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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.6
- 수록면
- 97 - 104 (8page)
- DOI
- 10.1186/s40824-018-0123-0
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초록· 키워드
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Background: Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparticle research is a representative example where click chemistry showed its promising potential. Challenging trials with nanoparticles has been reported based on click chemistry including copper-catalyzed cycloaddition, strain-promoted azide-alkyne cycloaddition, and inverse-demand Diels-Alder reaction. Main body: Herein, we provide an update on recent application of click chemistry in nanoparticle research, particularly nanoparticle modification and its targeted delivery. In nanoparticle modification, click chemistry has been generally used to modify biological ligands after synthesizing nanoparticles without changing the function of nanoparticles. Also, click chemistry in vivo can enhance targeting ability of nanoparticles to disease site. Conclusion: These applications in nanoparticle research were hard or impossible in case of traditional chemical reactions and demonstrating the great utility of click chemistry.
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참고문헌 (28)
참고문헌 신청
Cheng Z / 2012 / Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities / Science 338:903~910
Niu Z / 2016 / Lipid-based nanocarriers for oral peptide delivery / Adv Drug Deliv Rev 106:337~354
Bae Y / 2009 / Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers / Adv Drug Deliv Rev 61:768~784
Xie J / 2011 / Surface-engineered magnetic nanoparticle platforms for Cancer imaging and therapy / Acc Chem Res 44:883~892
Xie J / 2010 / Nanoparticle-based theranostic agents / Adv Drug Deliv Rev 62:1064~1079
Niu Z / 2016 / Lipid-based nanocarriers for oral peptide delivery / Adv Drug Deliv Rev 106:337~354
Bae Y / 2009 / Intelligent polymeric micelles from functional poly(ethylene glycol)-poly(amino acid) block copolymers / Adv Drug Deliv Rev 61:768~784
Xie J / 2011 / Surface-engineered magnetic nanoparticle platforms for Cancer imaging and therapy / Acc Chem Res 44:883~892
Xie J / 2010 / Nanoparticle-based theranostic agents / Adv Drug Deliv Rev 62:1064~1079
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