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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 367 - 382 (16page)
- DOI
- https://doi.org/10.1186/s40824-021-00229-3
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초록· 키워드
오류제보하기
Bone is a complex structure with unique cellular and molecular process in its formation. Bone tissue regeneration is a well-organized and routine process at the cellular and molecular level in humans through the activation of biochemical pathways and protein expression. Though many forms of biomaterials have been applied for bone tissue regeneration, electrospun nanofibrous scaffolds have attracted more attention among researchers with their physicochemical properties such as tensile strength, porosity, and biocompatibility. When drugs, antibiotics, or functional nanoparticles are taken as additives to the nanofiber, its efficacy towards the application gets increased. Polyphenol is a versatile green/phytochemical small molecule playing a vital role in several biomedical applications, including bone tissue regeneration. When polyphenols are incorporated as additives to the nanofibrous scaffold, their combined properties enhance cell attachment, proliferation, and differentiation in bone tissue defect. The present review describes bone biology encompassing the composition and function of bone tissue cells and exemplifies the series of biological processes associated with bone tissue regeneration. We have highlighted the molecular mechanism of bioactive polyphenols involved in bone tissue regeneration and specified the advantage of electrospun nanofiber as a wound healing scaffold. As the polyphenols contribute to wound healing with their antioxidant and antimicrobial properties, we have compiled a list of polyphenols studied, thus far, for bone tissue regeneration along with their in vitro and in vivo experimental biological results and salient observations. Finally, we have elaborated on the importance of polyphenol-loaded electrospun nanofiber in bone tissue regeneration and discussed the possible challenges and future directions in this field.
목차
등록된 정보가 없습니다.
참고문헌 (110)
참고문헌 신청
Scalbert A / 2005 / Dietary polyphenols and the prevention of diseases / Crit Rev Food Sci Nutr 45:287~306
나동균 / 2007 / Protection of Rabbit Kidney from Ischemia/Reperfusion Injury by Green Tea Polyphenol Pretreatment / Archives of Pharmacal Research 30(11):1447~1454
Nicolin V / 2019 / Modulatory effects of plant polyphenols on bone remodeling : a prospective view from the bench to bedside / Front Endocrinol 10:494
Park YH / 2003 / Protective effects of green tea polyphenol against reactive oxygen species-induced oxidative stress in cultured rat calvarial osteoblast / Cell Biol Toxicol 19:325~337
Rah DK / 2005 / Prevention of reactive oxygen species-induced oxidative stress in human microvascular endothelial cells by green tea polyphenol / Toxicol Lett 155:269~275
나동균 / 2007 / Protection of Rabbit Kidney from Ischemia/Reperfusion Injury by Green Tea Polyphenol Pretreatment / Archives of Pharmacal Research 30(11):1447~1454
Nicolin V / 2019 / Modulatory effects of plant polyphenols on bone remodeling : a prospective view from the bench to bedside / Front Endocrinol 10:494
Park YH / 2003 / Protective effects of green tea polyphenol against reactive oxygen species-induced oxidative stress in cultured rat calvarial osteoblast / Cell Biol Toxicol 19:325~337
Rah DK / 2005 / Prevention of reactive oxygen species-induced oxidative stress in human microvascular endothelial cells by green tea polyphenol / Toxicol Lett 155:269~275
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