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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Branched-chain amino acids (BCAAs), isoleucine, leucine and valine, are essential amino acids with vital roles in protein synthesis and energy production. We reviewed the fundamentals of BCAA metabolism in advanced cancer patients. BCAAs and various catabolic products act as signalling molecules, which activate mechanisms ranging from protein synthesis to insulin secretion. Re cently, BCAA metabolism has been suggested to contribute to cancer progression. Of particular interest is the modulation of the mTOR activity by BCAAs. There are likely multiple pathways involved in BCAA metabolism implicated in carcinogenesis. Under standing the mechanism(s) underlying altered BCAAs metabolism will significantly advance the current understanding of nutrient involvement in carcinogenesis and direct future studies to unravel the significance of BCCA metabolites in tumor development and progression.
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참고문헌 (79)
참고문헌 신청
DeBerardinis RJ / 2016 / Fundamentals of cancer metabolism / Sci Adv 2:e1600200
Martínez-Reyes I / 2021 / Cancer metabolism : looking forward / Nat Rev Cancer 21:669~680
Donaldson MS / 2004 / Nutrition and cancer : a review of the evidence for an anti-cancer diet / Nutr J 3:19
Ravasco P / 2019 / Nutrition in cancer patients / J Clin Med 8:1211
Bingham S / 2004 / Diet and cancer--the European Prospective Investigation into Cancer and Nutrition / Nat Rev Cancer 4:206~215
Martínez-Reyes I / 2021 / Cancer metabolism : looking forward / Nat Rev Cancer 21:669~680
Donaldson MS / 2004 / Nutrition and cancer : a review of the evidence for an anti-cancer diet / Nutr J 3:19
Ravasco P / 2019 / Nutrition in cancer patients / J Clin Med 8:1211
Bingham S / 2004 / Diet and cancer--the European Prospective Investigation into Cancer and Nutrition / Nat Rev Cancer 4:206~215
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