지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 732 - 741 (10page)
- DOI
- 10.5009/gnl20249
이용수
초록· 키워드
오류제보하기
Background/Aims: The diagnosis of small bowel Crohn’s disease with negative ileocolonoscopic findings has been challenging. Fecal calprotectin (FC) has been used to detect colonic inflammation, but its efficacy for detecting small bowel inflammation is less established. We performed an updated meta-analysis to evaluate the diagnostic accuracy of FC to detect active small bowel inflammation observed during capsule endoscopy.
Methods: We conducted a systematic literature search for studies that evaluated the correlation between small bowel inflammation and FC in patients with suspected/established Crohn’s disease. We calculated the pooled sensitivity, specificity, and diagnostic odds ratios (DORs) and constructed hierarchical summary receiver operating characteristic curves for FC cutoffs of 50, 100, and 200 μg/g.
Results: Fourteen studies were eligible for the final analysis. The DORs of all FC cutoffs were significant. The highest DOR was observed at 100 μg/g (sensitivity, 0.73; specificity, 0.73; and DOR, 7.89) and was suggested as the optimal diagnostic cutoff. If we analyzed only studies that included patients with suspected Crohn’s disease, the DOR was 8.96. If we analyzed only studies that included patients with a Lewis score ≥135 as a diagnostic criterion for active disease, the DOR was 10.90.
Conclusions: FC has significant diagnostic accuracy for detecting small bowel inflammation, and an FC cutoff of 100 μg/g can be used as a tool to screen for small bowel Crohn’s disease.
목차
등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Torres J / 2017 / Crohn’s disease / Lancet 389:1741~1755
Abdul-Baki H / 2007 / Clinical epidemiology of inflammatory bowel disease in Lebanon / Inflamm Bowel Dis 13:475~480
Park SH / 2019 / A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong District of Seoul, Korea in 1986-2015 / J Crohns Colitis 13:1410~1417
백승혁 / 2013 / Characteristic Phenotypes in Korean Crohn’s Disease Patients Who Underwent Intestinal Surgery for the Treatment / Journal of Korean Medical Science 28(4):575~579
Gower-Rousseau C / 2013 / Epidemiology of inflammatory bowel diseases : new insights from a French population-based registry(EPIMAD) / Dig Liver Dis 45:89~94
Abdul-Baki H / 2007 / Clinical epidemiology of inflammatory bowel disease in Lebanon / Inflamm Bowel Dis 13:475~480
Park SH / 2019 / A 30-year trend analysis in the epidemiology of inflammatory bowel disease in the Songpa-Kangdong District of Seoul, Korea in 1986-2015 / J Crohns Colitis 13:1410~1417
백승혁 / 2013 / Characteristic Phenotypes in Korean Crohn’s Disease Patients Who Underwent Intestinal Surgery for the Treatment / Journal of Korean Medical Science 28(4):575~579
Gower-Rousseau C / 2013 / Epidemiology of inflammatory bowel diseases : new insights from a French population-based registry(EPIMAD) / Dig Liver Dis 45:89~94
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Optimal Cutoff Level of Fecal Calprotectin for Detecting Small Bowel Inflammation in Crohn's Disease
Gut and Liver
2021 .09
-
Does fecal calprotectin equally and accurately measure disease activity in small bowel and large bowel Crohn’s disease?: a systematic review
Intestinal research
2019 .01
-
Is Effective of Capsule Endoscopy Compared to Other Diagnostic Modalities in Patients with Small Bowel Crohn’s Disease?
Gut and Liver
2017 .01
-
The role of fecal calprotectin in pediatric disease
Clinical and Experimental Pediatrics
2019 .01
-
Balloon-Assisted Enteroscopy and Capsule Endoscopy in Suspected Small Bowel Crohn’s Disease
Clinical Endoscopy
2017 .01
-
Radiologic images of complications of Crohn's disease
International Journal of Gastrointestinal Intervention
2023 .01
-
Optimal Diagnostic Approaches for Patients with Suspected Small Bowel Disease
Clinical Endoscopy
2016 .01
-
Intestinal ultrasonography and fecal calprotectin for monitoring inflammation of ileal Crohn’s disease: two complementary tests
Intestinal research
2022 .07
-
Which biomarkers best reflect the degree of inflammation in Crohn’s disease?
Intestinal research
2024 .01
-
Accuracy of three different fecal calprotectin tests in the diagnosis of inflammatory bowel disease
Intestinal research
2016 .01
-
Effectiveness of Capsule Endoscopy Compared with Other Diagnostic Modalities in Patients with Small Bowel Crohn’s Disease: A Meta-Analysis
Gut and Liver
2017 .01
-
Oral Symptoms Related to Vitamin B12 Deficiency in a Patient with Crohn’s Disease
Journal of Oral Medicine and Pain
2018 .12
-
Capsule endoscopy in inflammatory bowel disease: when and how
Intestinal research
2020 .01
-
Fecal Calprotectin at Postinduction Is Capable of Predicting Persistent Remission and Endoscopic Healing after 1 Year of Treatment with Infliximab in Pediatric Patients with Crohn’s Disease
Gut and Liver
2024 .05
-
염증성 장질환의 약물요법
대한의사협회지
2015 .01
-
Fecal Calprotectin and Phenotype Severity in Patients with Cystic Fibrosis: A Systematic Review and Meta-Analysis
Pediatric Gastroenterology, Hepatology & Nutrition
2022 .01
-
Precision medicine in inflammatory bowel diseases
Intestinal research
2024 .01
-
Role of capsule endoscopy in suspected or established Crohn’s disease in real practice
Intestinal research
2017 .01
-
Pediatric Magnetic Resonance Enterography: Focused on Crohn’s Disease
Pediatric Gastroenterology, Hepatology & Nutrition
2015 .01
-
Fecal S100A12 is associated with future hospitalization and step-up of medical treatment in patients with Crohn’s disease in clinical remission: a pilot study
Intestinal research
2022 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0