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자료유형
학술저널
저자정보
배종면 (제주대학교)
저널정보
대한보건협회 대한보건연구 대한보건연구 제47권 제3호
발행연도
2021.8
수록면
1 - 10 (10page)

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Objectives: Consistent inverse relationships between circulating vitamin D level and risk of colorectal cancer and breast cancer were found. However, previous systematic reviews reported that higher circulating vitamin D level increases the prostate cancer risk. In this meta-epidemiological review, the author will summarize the results of previous systematic reviews evaluating the association between circulating 25-hydroxyvitamin D levels and prostate cancer risk. Methods: The subjects were previous systematic reviews for evaluating the association between serum vitamin D levels and prostate cancer risk. To suggest some new hypotheses, an updated dose-response meta-analysis for follow-up studies was conducted. Results: Previous systematic reviews showed that many epidemiological studies published before 2014 had investigated the hypothesis about the increased risk of prostate cancer associated with vitamin D deficiency/insufficiency. However, the opposite results of the previous hypothesis were derived as the number of papers selected for meta-analysis exceeded 19. Subgroup analysis by study design showed that significant results showed in 17 nested case-control studies and in five follow-up studies. Dose-response meta-analysis had a statistical significance in nested case-control studies, not in follow-up studies. Significance of Results: Six major hypotheses such as heterogeneity of prostate cancer, a healthy screened bias, a non-linear U-shaped relationship, a tumor-promoting effects of vitamin D, the engaging effect of vitamin D in initiation or progression stage, and some single-nucleotide polymorphisms of the vitamin D receptor gene, have been suggested about how vitamin D has an opposite direction of risk between the prostate and other cancers.

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