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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 46 - 50 (5page)
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Combination treatment with hypomethylating agents (HMAs) and venetoclax is being used increasingly in elderly patients with acute myeloid leukemia (AML).
Venetoclax with HMAs has been reported to be associated with tumor lysis syndrome (TLS) in AML patients with high leukemic burden. We present a case of an elderly AML patient with low leukemic burden who developed TLS while receiving venetoclax and azacitidine (AZA). A 74-year-old man with newly diagnosed AML with NPM1 mutation received combination therapy with venetoclax and AZA in an outpatient clinic. Within 12 hours after starting venetoclax and AZA, the patient was admitted to the emergency room with fever, general weakness, and laboratory findings consistent with TLS. Based on our results, we recommend monitoring at the start of the treatment with venetoclax and HMAs to prevent and control TLS regardless of the leukemic burden and favorable genetic risk.
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참고문헌 (18)
참고문헌 신청
DiNardo CD / 2019 / Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia / Blood 133:7~17
Bogenberger JM / 2014 / BCL-2family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies / Leukemia 28:1657~1665
Pollyea DA / 2019 / Venetoclax for AML : changing the treatment paradigm / Blood Adv 3:4326~4335
Keruakous A / 2020 / Venetoclax-induced tumor lysis syndrome in acute myeloid leukemia: Real world experience / Journal of Clinical Oncology 38(15_suppl):e19542~e19542
Esparza S / 2020 / Venetoclax-induced tumour lysis syndrome in acute myeloid leukaemia / British Journal of Haematology 188:173~177
Bogenberger JM / 2014 / BCL-2family proteins as 5-Azacytidine-sensitizing targets and determinants of response in myeloid malignancies / Leukemia 28:1657~1665
Pollyea DA / 2019 / Venetoclax for AML : changing the treatment paradigm / Blood Adv 3:4326~4335
Keruakous A / 2020 / Venetoclax-induced tumor lysis syndrome in acute myeloid leukemia: Real world experience / Journal of Clinical Oncology 38(15_suppl):e19542~e19542
Esparza S / 2020 / Venetoclax-induced tumour lysis syndrome in acute myeloid leukaemia / British Journal of Haematology 188:173~177
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