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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 557 - 562 (6page)
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이 논문의 연구 히스토리 (4)
2021
Anti-inflammatory effects of N-cyclooctyl-5-methylthiazol-2-amine hydrobromide on lipopolysaccharide-induced inflammatory response through attenuation of NLRP3 activation in microglial cells
Eun-A Kim
,
Kyouk Hwang
,
Ji-Eun Kim
외 4명
BMB Reports
2021.11
학술저널
Enhancement of anti-inflammatory effect of tuberatolide B via MAPKs and NF-κB signalings pathway in RAW264.7 cells and zebrafish model
Eun-A Kim
,
Nalae-Kang
,
Junseong Kim
외 1명
한국수산과학회 양식분과 학술대회
2021.04
학술대회자료
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Microglial activation is closely associated with neuroinflammatorypathologies. The nucleotide-binding and oligomerizationdomain-like receptor containing a pyrin domain 3 (NLRP3) inflammasomesare highly organized intracellular sensors of neuronalalarm signaling. NLRP3 inflammasomes activate nuclearfactor kappa-B (NF-κB) and reactive oxygen species (ROS), whichinduce inflammatory responses. Moreover, NLRP3 dysfunctionis a common feature of chronic inflammatory diseases. The presentstudy investigated the effect of a novel thiazol derivative,N-cyclooctyl-5-methylthiazol-2-amine hydrobromide (KHG26700),on inflammatory responses in lipopolysaccharide (LPS)-treatedBV-2 microglial cells. KHG26700 significantly attenuated theexpression of several pro-inflammatory cytokines, including tumornecrosis factor-α, interleukin-1β, and interleukin-6, in these cells,as well as the LPS-induced increases in NLRP3, NF-κB, andphospho-IkBα levels. KHG26700 also suppressed the LPS-inducedincreases in protein levels of autophagy protein 5 (ATG5), microtubule-associated protein 1 light chain 3 (LC3), and beclin-1,as well as downregulating the LPS-enhanced levels of ROS,lipid peroxidation, and nitric oxide. These results suggest thatthe anti-inflammatory effects of KHG26700 may be due, at leastin part, to the regulation of the NLRP3-mediated signaling pathwayduring microglial activation.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Lee CM / 2016 / Benzyl isothiocyanate inhibits inflammasome activation in E. coli LPSstimulated BV2 cells / Int Mol Med 38:912~918
Budai MM / 2013 / Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages / Mol Immunol 56:471~479
inarello CA / 2009 / Immunological and inflammatory functions of the interleukin-1 family / Annu Rev Immunol 27:519~550
Jeng KCG / 2005 / Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB / Immunol Lett 97:101~106
Fu YY / 2014 / Mangiferin regulates interleukin-6 and cystathionine-b-synthase in lipopolysaccharide-induced brain injury / Cell Mol Neurobiol 34:651~657
Budai MM / 2013 / Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages / Mol Immunol 56:471~479
inarello CA / 2009 / Immunological and inflammatory functions of the interleukin-1 family / Annu Rev Immunol 27:519~550
Jeng KCG / 2005 / Sesamin inhibits lipopolysaccharide-induced cytokine production by suppression of p38 mitogen-activated protein kinase and nuclear factor-kappaB / Immunol Lett 97:101~106
Fu YY / 2014 / Mangiferin regulates interleukin-6 and cystathionine-b-synthase in lipopolysaccharide-induced brain injury / Cell Mol Neurobiol 34:651~657
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Combination of Human Mesenchymal Stem Cells and Repetitive Transcranial Magnetic Stimulation Enhances Neurological Recovery of 6-Hydroxydopamine Model of Parkinsonian’s Disease
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Publisher Correction: Acetate attenuates inflammasome activation through GPR43- mediated Ca2+-dependent NLRP3 ubiquitination
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Anti-inflammatory mechanisms of suppressors of cytokine signaling target ROS via NRF-2/thioredoxin induction and inflammasome activation in macrophages
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Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis
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Anti-inflammatory effect of tuna spermary ethanol extract in LPS-induced Raw 264.7 cells and mouse models
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