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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objective: Creatine, energy buffer in high energy demanding systems including muscle and brain, may play a beneficial role against neuroinflammation in Alzheimer’s disease (AD), and thus be a potential biomarker. This study aimed to compare the levels of plasma creatine between persons with and without AD and investigate associations of plasma creatine levels with cognitive function and blood-based inflammatory markers.
Methods: We classified elderly participants by cognitive statuses: normal cognition (NC, n=17), mild cognitive impairment (MCI, n=21), and AD (n=21). To assess cognitive function and inflammatory condition, we performed neuropsychological tests and measured plasma C-reactive protein (CRP) levels, respectively.
Results: Plasma creatine levels were comparable among participants with AD, MCI, and NC. In overall participants, plasma creatine levels were not associated with neuropsychological test scores, but negatively associated with plasma CRP levels. In AD group, plasma creatine levels were negatively associated with neuropsychological test scores and, although not significant, CRP levels (p=0.086). In participants without AD (NC plus MCI), these associations disappeared.
Conclusion: Plasma creatine levels may not be useful as a biomarker indicating cognitive statuses. However, our results suggest that, in AD, plasma levels of creatine might reflect the extent of neuroinflammation as well as cognitive deterioration.
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참고문헌 (39)
참고문헌 신청
Jack Jr CR / 2010 / Hypothetical model of dynamic biomarkers of the Alzheimer’s pathological cascade / Lancet Neurol 9:119~128
Grundke-Iqbal I / 1986 / Abnormal phosphorylation of the microtubule-associated protein tau(tau)in Alzheimer cytoskeletal pathology / Proc Natl Acad Sci U S A 83:4913~4917
Heneka MT / 2015 / Neuroinflammation in Alzheimer’s disease / Lancet Neurol 14:388~405
McGeer PL / 2016 / Inflammation, antiinflammatory agents, and Alzheimer’s disease: the last 22 years / J Alzheimers Dis 54:853~857
Shen XN / 2019 / Inflammatory markers in Alzheimer’s disease and mild cognitive impairment : a meta-analysis and systematic review of 170 studies / J Neurol Neurosurg Psychiatry 90:590~598
Grundke-Iqbal I / 1986 / Abnormal phosphorylation of the microtubule-associated protein tau(tau)in Alzheimer cytoskeletal pathology / Proc Natl Acad Sci U S A 83:4913~4917
Heneka MT / 2015 / Neuroinflammation in Alzheimer’s disease / Lancet Neurol 14:388~405
McGeer PL / 2016 / Inflammation, antiinflammatory agents, and Alzheimer’s disease: the last 22 years / J Alzheimers Dis 54:853~857
Shen XN / 2019 / Inflammatory markers in Alzheimer’s disease and mild cognitive impairment : a meta-analysis and systematic review of 170 studies / J Neurol Neurosurg Psychiatry 90:590~598
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