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자료유형
학술저널
저자정보
윤은정 (한국교원대학교) 김경래 (한국교원대학교) 박동선 (한국교원대학교)
저널정보
한국교원대학교 뇌기반교육연구소 Brain, Digital, & Learning Brain, Digital, & Learning Vol.11 No.4
발행연도
2021.12
수록면
577 - 587 (11page)
DOI
https://doi.org/10.31216/BDL.20210037

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This study aimed to investigate the impact of brain neuroplasticity-related factors’ mRNA expression patterns in the hippocampus and cognitive function in ovariectomized rats following resistance exercise. Twenty-week-old female SD rats (n=30) were randomly divided into normal control (NC, n=10), ovariectomy (OVX, n=10), and ovariectomy + resistance exercise (OVX+REX, n=10) groups. A ladder-climbing exercise, in which rats climbed to the top of ladder with a weight applied to their tails 8 times a day, 3 days a week for 12 weeks, was used for resistance training. After 12 weeks, rats from the OVX group had higher body weights and were significantly lower in the OVX-REX group than in the OVX group. The mRNA expression levels of the brain neuroplasticity-related genes, BDNF, IGF-1 and VEGF were significantly decreased by ovariectomy. However, they were significantly increased in the OVX+REX group compared to that in the OVX group. In addition, the learning and memory function of rats in the OVX group was significantly improved by resistance exercise. These results suggest that resistance exercise contributing to improved learning and memory function may be in part due to increased mRNA expression of brain neuroplasticity-related factors in ovariectomized rats.

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