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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.11
- 수록면
- 1 - 23 (23page)
- DOI
- 10.1186/s40580-021-00288-1
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Nanoparticles have drawn intense interest as delivery agents for diagnosing and treating various cancers. Much of the early success was driven by passive targeting mechanisms such as the enhanced permeability and retention (EPR) effect, but this has failed to lead to the expected clinical successes. Active targeting involves binding interactions between the nanoparticle and cancer cells, which promotes tumor cell-specific accumulation and internalization. Furthermore, nanoparticles are large enough to facilitate multiple bond formation, which can improve adhesive properties substantially in comparison to the single bond case. While multivalent binding is universally believed to be an attribute of nanoparticles, it is a complex process that is still poorly understood and difficult to control. In this review, we will first discuss experimental studies that have elucidated roles for parameters such as nanoparticle size and shape, targeting ligand and target receptor densities, and monovalent binding kinetics on multivalent nanoparticle adhesion efficiency and cellular internalization. Although such experimental studies are very insightful, information is limited and confounded by numerous differences across experimental systems. Thus, we focus the second part of the review on theoretical aspects of binding, including kinetics, biomechanics, and transport physics. Finally, we discuss various computational and simulation studies of nanoparticle adhesion, including advanced treatments that compare directly to experimental results. Future work will ideally continue to combine experimental data and advanced computational studies to extend our knowledge of multivalent adhesion, as well as design the most powerful nanoparticle-based agents to treat cancer.
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참고문헌 (112)
참고문헌 신청
H. Sung / 2021 / Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries / CA 71(3):209~249
E. L. Aaronson / 2019 / Missed diagnosis of cancer in primary care: Insights from malpractice claims data / J. Healthc. Risk Manag 39(2):19~29
M. E. Davis / 2008 / Nanoparticle therapeutics: an emerging treatment modality for cancer / Nat. Rev. Drug Discov 7(9):771~782
S. Sim / 2021 / Nanotechnology and its use in imaging and drug delivery (Review) / Biomed. Rep 14(5):1~9
Z. Yu / 2021 / Nanoparticles: a new approach to upgrade cancer diagnosis and treatment / Nanoscale Res. Lett 16(1):88
E. L. Aaronson / 2019 / Missed diagnosis of cancer in primary care: Insights from malpractice claims data / J. Healthc. Risk Manag 39(2):19~29
M. E. Davis / 2008 / Nanoparticle therapeutics: an emerging treatment modality for cancer / Nat. Rev. Drug Discov 7(9):771~782
S. Sim / 2021 / Nanotechnology and its use in imaging and drug delivery (Review) / Biomed. Rep 14(5):1~9
Z. Yu / 2021 / Nanoparticles: a new approach to upgrade cancer diagnosis and treatment / Nanoscale Res. Lett 16(1):88
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