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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 171 - 176 (6page)
- DOI
- 10.13041/jpvm.2018.42.4.171
이용수
초록· 키워드
오류제보하기
A study of the tissue depletion of florfenicol (FFC) administered orally to pigs at a dose of 0.05 kg/ton feed for 7 days was performed. Sixteen healthy cross swine were administered with FFC. Four treated animals were arbitrarily selected to be sacrificed 1, 3 and 5 days after the end of treatment. FFC residue concentrations in muscle, liver, kidney, and fat were determined using high-performance liquid chromatography (HPLC) with ultraviolet photometric detector at 230 nm. The correlation coefficient (R2) of the calibration curve for florfenicol amine (FFCa) was > 0.997 and the limits of detection and quantification were 0.012 and 0.040 μg/mL, respectively. Recovery rates in swine edible tissues ranged from 79.1 to 93.5%. In the FFC-treated group, FFC residues at 3 days post-treatment were below the maximum residue limits (MRLs) in muscle, kidney and fat, and those at 5 days post-administration were below the MRLs in all edible tissues. These results suggest that the withdrawal period of FFC after the drug treatment might be 5 days, which is a sufficient amount of time for reduction of the FFC residues below the MRLs in all edible tissues.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Birdane YO / 2015 / Pharmacokinetics of florfenicol following intravenous and intramuscular administration in dogs / Vet Med (Praha) 60:323~329
Christopher L / 2003 / Determination of florfenicol amine in channel catfish muscle by liquid chromatography / J AOAC Int 86:515~520
Codex Alimentarius Commission / 1993 / Codex guidelines for the establishment of a regulatory program for control of veterinary drug residues in foods. Part III. Attributes of analytical methods for residues of veterinary drugs in foods. CAC/GL16 / Food and Agriculture Organization in the United Nations :38~43
Committee for Veterinary Medicinal Products / 1999 / The European Agency for the Evaluation of Medicinal Products. Florfenicol (extension to pigs), Summary Report :1~4
European commission / 2010 / Commission regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin / OJEU :53
Christopher L / 2003 / Determination of florfenicol amine in channel catfish muscle by liquid chromatography / J AOAC Int 86:515~520
Codex Alimentarius Commission / 1993 / Codex guidelines for the establishment of a regulatory program for control of veterinary drug residues in foods. Part III. Attributes of analytical methods for residues of veterinary drugs in foods. CAC/GL16 / Food and Agriculture Organization in the United Nations :38~43
Committee for Veterinary Medicinal Products / 1999 / The European Agency for the Evaluation of Medicinal Products. Florfenicol (extension to pigs), Summary Report :1~4
European commission / 2010 / Commission regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin / OJEU :53
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