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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 177 - 181 (5page)
- DOI
- 10.13041/jpvm.2018.42.4.177
이용수
초록· 키워드
오류제보하기
Disulfiram is a drug used to treat alcohol dependence. Recent studies have shown that disulfiram also has anti-cancer effects. Considering that many anti-cancer agents have side effects, including immunosuppression, it is important to check if disulfiram has some cytotoxicity to immune cells. In this study, mouse spleen cells were treated with disulfiram and the metabolic activity was measured. Disulfiram increased the cell death of spleen cells according to annexin V-FITC/PI staining analysis. In addition, disulfiram decreased the mitochondrial membrane potential of spleen cells. The toxicity of disulfiram was concentration dependent. Interestingly, disulfiram affected the population of lymphocytes and the subset of spleen cells was altered. This study provides clinicians and researchers with valuable information regarding the toxicity of disulfiram to mouse spleen cells, particularly lymphocytes.
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
안소연 / 2018 / Anti-inflammatory activity of Caesalpinia sappan extract on lipopolysaccharide-treated bone marrow cells / 예방수의학회지 42(3):107~111
Azrin NH / 1982 / Alcoholism treatment by disulfiram and community reinforcement therapy / J Behav Ther Exp Psychiatry 13:105~112
Chen LB / 1988 / Mitochondrial membrane potential in living cells / Annu Rev Cell Biol 4:155~181
Franchi S / 2010 / The effects of alcoholism pharmacotherapy on immune responses in alcoholdependent patients / Int J Immunopathol Pharmacol 23:847~855
Yong Han / 2015 / Protective effects of fucoidan on the cell death of spleen cells induced by taxol / 예방수의학회지 39(4):185~188
Azrin NH / 1982 / Alcoholism treatment by disulfiram and community reinforcement therapy / J Behav Ther Exp Psychiatry 13:105~112
Chen LB / 1988 / Mitochondrial membrane potential in living cells / Annu Rev Cell Biol 4:155~181
Franchi S / 2010 / The effects of alcoholism pharmacotherapy on immune responses in alcoholdependent patients / Int J Immunopathol Pharmacol 23:847~855
Yong Han / 2015 / Protective effects of fucoidan on the cell death of spleen cells induced by taxol / 예방수의학회지 39(4):185~188
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