지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 204 - 210 (7page)
- DOI
- 10.4068/cmj.2021.57.3.204
이용수
초록· 키워드
오류제보하기
Potent antiplatelet therapy after primary percutaneous coronary intervention (PCI) has the potential to reduce infarct size. This study analyzed the association between on-treatment platelet reactivity and myocardial infarct size in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI. In this single-center, retrospective study, 253 patients who underwent primary PCI for STEMI were divided into two groups according to platelet reactivity measurements (53 patients in the high platelet reactivity [HPR] group and 200 in the non-HPR group). Technetium Tc-99m tetrofosmin single-photon emission computed tomography (SPECT) was performed before hospital discharge. We measured the infarct size using SPECT imaging and serial cardiac biomarker levels, and compared the infarct sizes of each group. The patients with HPR were older (65.5±13.2 vs. 60.6±12.1 years, p=0.011) than the patients with non-HPR. On the other hand, the non-HPR group had a higher incidence of smoking (26.4% vs. 51.0%, p=0.001) than the HPR group. Infarct size was similar between the two groups (22.6±17.3% vs. 24.8±17.7%, p=0.416). Multivariate analysis revealed that onset to balloon time >240 min (odds ratio [OR]=1.92; 95% confidence interval [CI]=1.08-3.40; p=0.025) and anterior infarction (OR=5.28; 95% CI=3.05-9.14; p<0.001) were independent predictors of large (>22%) infarct size. HPR was not a predictor of infarct size assessed by SPECT. The two groups also showed analogous cumulative creatinine kinase-myocardial band and troponin T levels. In conclusion, compared to non-HPR, HPR showed no significant association with myocardial infarct size measured by SPECT imaging in early phase of MI.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Stone GW / 2016 / Relationship between infarct size and outcomes following primary PCI : patient-level analysis from 10 randomized trials / J Am Coll Cardiol 67:1674~1683
Petriz JL / 2015 / Assessment of myocardial infarction by cardiac magnetic resonance imaging and long-term mortality / Arq Bras Cardiol 104:159~168
Herlitz J / 1988 / The relationship between infarct size and mortality and morbidity during shortterm and long-term follow-up after acute myocardial infarction / Am Heart J 116(5):1378~1382
Burns RJ / 2002 / The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis / J Am Coll Cardiol 39:30~36
Miller TD / 1999 / Comparison of acute myocardial infarct size to two-year mortality in patients <65 to those> or =65 years of age / Am J Cardiol 84:1170~1175
Petriz JL / 2015 / Assessment of myocardial infarction by cardiac magnetic resonance imaging and long-term mortality / Arq Bras Cardiol 104:159~168
Herlitz J / 1988 / The relationship between infarct size and mortality and morbidity during shortterm and long-term follow-up after acute myocardial infarction / Am Heart J 116(5):1378~1382
Burns RJ / 2002 / The relationships of left ventricular ejection fraction, end-systolic volume index and infarct size to six-month mortality after hospital discharge following myocardial infarction treated by thrombolysis / J Am Coll Cardiol 39:30~36
Miller TD / 1999 / Comparison of acute myocardial infarct size to two-year mortality in patients <65 to those> or =65 years of age / Am J Cardiol 84:1170~1175
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