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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 157 - 164 (8page)
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New enrofloxacin microspheres were formulated, and their physical properties, lung-targeting ability, and tissue distribution in rats were examined. The microspheres had a regular and round shape. The mean diameter was 10.06 um, and the diameter of 89.93% of all microspheres ranged from 7.0 um to 30.0 um. Tissue distribution of the microspheres was evaluated along with a conventional enrofloxacin preparation after a single intravenous injection (7.5 mg of enrofloxacin/kg bw). The results showed that the elimination half-life (t<sub>1/2β</sub>) of enrofloxacin from lung was prolonged from 7.94 h for the conventional enrofloxacin to 13.28 h for the microspheres. Area under the lung concentration versus time curve from 0 h to ∞ (AUC<sub>0-∞</sub>) was increased from 11.66 h·ug/g to 508.00 h·ug/g. The peak concentration (C<sub>max</sub>) in lung was increased from 5.95 ug/g to 93.36 ug/g. Three lung-targeting parameters were further assessed and showed that the microspheres had remarkable lung-targeting capabilities.
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