지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 597 - 604 (8page)
이용수
초록· 키워드
오류제보하기
SA ?-Gal activity is a key marker of cellular senescence. The origin of this activity is the lysosomal ?-galactosidase, whose activity has increased high enough to be detected at suboptimal pH. SA ?-Gal is also expressed in the cells in quiescence driven by serum-starvation or a high confluency, and it has been hypothesized that SA ?-Gal positivity is rather a surrogate marker of high lysosome content or activity. In this study, it was determined how SA ?-Gal activity is expressed in quiescence and how lysosome content and activities are differently maintained in senescence and quiescence using DNA damage-induced senescence and serum starvation-induced quiescence as study models. Lysosome content increased to facilitate SA ?-Gal expression in both the conditions but with a big dif-ference in the levels of the change. Lipofuscins whose accumulation leads to an increase in residual bodies also increased but with a smaller difference between the two conditions. Meanwhile, lysosome biogenesis was actively ongoing only in senescence progression, indicating that the difference in the lysosome contents may largely be due to lysosome biogenesis. Further, the cells undergoing senescence progression but not the ones in quiescence maintained high mTOR and low autophagy activities. Overall, the results indicate that, although SA ?-Gal is expressed due to the elevated lysosome content in both cellular senescence and quiescence, senescence differs from quiescence with high lysosome biogenesis and low autophagy activity, and mTOR activity might be involved in these differences.
목차
등록된 정보가 없습니다.
참고문헌 (2)
참고문헌 신청
Sohee Cho / 2011 / Kinetics of the Cell Biological Changes Occurring in the Progression of DNA Damage-Induced Senescence / Molecules and Cells 31(6):539~546
박지훈 / 2007 / Heterogeneous Upregulation of Lysosomal Genes in Human Fibroblasts and Cancer Cells Undergoing Senescence / Genes & Genomics 29(4):521~527
박지훈 / 2007 / Heterogeneous Upregulation of Lysosomal Genes in Human Fibroblasts and Cancer Cells Undergoing Senescence / Genes & Genomics 29(4):521~527
이 논문의 저자 정보
최근 본 자료
댓글(0)
0