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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.8
- 수록면
- 201 - 208 (8page)
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The hematopoietic cell malignancy is one of the most prevalent type of cancer and the disease has multiple pathologic molecular signatures. Research on the origin of hematopoietic cancer stem cells and the mode of subsequent maintenance and differentiation needs robust animal models that can reproduce the transformation and differentiation event in vivo. Here, we show that co-trans-duction of MYC and PIM2 proto-oncogenes into mouse bone marrow cells readily establishes permanent cell lines that can induce lethal myeloid sarcoma in vivo. Unlike the previous doubly transgenic mouse model in which co-expression of MYC and PIM2 transgenes exclusively induced B cell lymphoma, we were able to show that the same combination of genes can also transform primary bone marrow myeloid cells in vitro resulting in permanent cell lines which induce myeloid sarcoma upon in vivo transplantation. By inducing cancerous transformation of fresh bone marrow cells in a controlled environment, the model we established will be useful for detailed study of the molecular events involved in initial transformation process of primary myeloid bone marrow cells and provides a model that can give insight to the molecular pathologic characteristics of human myeloid sarcoma, a rare presentation of solid tumors of undifferentiated myeloid blast cells associated with various types of myeloid leukemia.
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참고문헌 (32)
참고문헌 신청
Allen, J. D. / 1997 / Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc / Oncogene 15:1133~1141
Brown, D. / 1997 / A PMLRARalpha transgene initiates murine acute promyelocytic leukemia / Proc. Natl. Acad. Sci 94:2551~2556
Cashman, J. D. / 1997 / Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice / Blood 89:4307~4316
Chen, W. W. / 2005 / Pim family kinases enhance tumor growth of prostatecancer cells / Mol. Cancer Res 3:443~451
Cheng, G. X. / 1999 / Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha / Proc. Natl. Acad. Sci 96:6318~6323
Brown, D. / 1997 / A PMLRARalpha transgene initiates murine acute promyelocytic leukemia / Proc. Natl. Acad. Sci 94:2551~2556
Cashman, J. D. / 1997 / Kinetic evidence of the regeneration of multilineage hematopoiesis from primitive cells in normal human bone marrow transplanted into immunodeficient mice / Blood 89:4307~4316
Chen, W. W. / 2005 / Pim family kinases enhance tumor growth of prostatecancer cells / Mol. Cancer Res 3:443~451
Cheng, G. X. / 1999 / Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARalpha and NPM-RARalpha / Proc. Natl. Acad. Sci 96:6318~6323
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