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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.6
- 수록면
- 463 - 473 (11page)
- DOI
- 10.1007/s10059-013-0138-2
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초록· 키워드
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The mammalian target of rapamycin (mTOR) is an evolu-tionally conserved kinase which exists in two distinct structural and functional complexes, mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). Of the two complexes, mTORC1 couples nutrient abundance to cell growth and proliferation by sensing and integrating a variety of inputs arising from amino acids, cellular stresses, energy status, and growth factors. Defects in mTORC1 regulation are implicated in the development of many metabolic diseases, including cancer and diabetes. Over the past decade, significant advances have been made in deciphering the complexity of the signaling processes contributing to mTORC1 regulation and function, but the mechanistic details are still not fully understood. In particular, how amino acid availability is sensed by cells and signals to mTORC1 remains unclear. In this review, we discuss the current understanding of nutrient-dependent control of mTORC1 signaling and will focus on the key components involved in amino acid signaling to mTORC1.
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참고문헌 (108)
참고문헌 신청
Ahearn, I.M / 2012 / Regulating the regulator: post-translational modification of RAS / Nat. Rev. Mol. Cell Biol 13:39~51
Ashrafi, K / 1998 / A role for Saccharomyces cerevisiae fatty acid activation protein 4 in regulating protein N-myristoylation during entry into stationary phase / J. Biol. Chem 273:25864~25874
Ballif, B.A / 2005 / Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors / Proc. Natl. Acad. Sci. USA 102:667~672
Bar-Peled, L / 2012 / Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 / Cell 150:1196~1208
Barbet, N.C / 1996 / TOR controls translation initiation and early G1 progression in yeast / Mol. Biol. Cell 7:25~42
Ashrafi, K / 1998 / A role for Saccharomyces cerevisiae fatty acid activation protein 4 in regulating protein N-myristoylation during entry into stationary phase / J. Biol. Chem 273:25864~25874
Ballif, B.A / 2005 / Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors / Proc. Natl. Acad. Sci. USA 102:667~672
Bar-Peled, L / 2012 / Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1 / Cell 150:1196~1208
Barbet, N.C / 1996 / TOR controls translation initiation and early G1 progression in yeast / Mol. Biol. Cell 7:25~42
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