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- 학술저널
- 저자정보
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- 2015.12
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Whole body energy balance is achieved through the coordinated regulation of energy intake and energy expenditure in various tissues including liver, muscle and adipose tissues. A positive energy imbalance by excessive energy intake or insufficient energy expenditure results in obesity and related metabolic diseases. Although there have been many obesity treatment trials aimed at the reduction of energy intake, these strategies have achieved only limited success because of their associated adverse effects. An ancient neurotransmitter, serotonin is among those traditional pharmacological targets for anti-obesity treatment because it exhibits strong anorectic effect in the brain.
However, recent studies suggest the new functions of peripheral serotonin in energy homeostasis ranging from the endocrine regulation by gut-derived serotonin to the autocrine/ paracrine regulation by adipocyte-derived serotonin.
Here, we discuss the role of serotonin in the regulation of energy homeostasis and introduce peripheral serotonin as a possible target for anti-obesity treatment.
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참고문헌 (58)
참고문헌 신청
Alenina, N. / 2009 / Growth retardation and altered autonomic control in mice lacking brain serotonin / Proc. Natl. Acad. Sci. USA 106:10332~10337
Arase, K. / 1988 / Effect of fenfluramine on sympathetic firing rate / Pharmacol. Biochem. Behav 29:675~680
Bertrand, R. L. / 2011 / A Western diet increases serotonin availability in rat small intestine / Endocrinology 152:36~47
Bouwknecht, J. A. / 2001 / Male and female 5-HT(1B)receptor knockout mice have higher body weights than wildtypes / Physiol. Behav 74:507~516
Brand, T. / 2011 / The measurement of plateletpoor plasma serotonin : a systematic review of prior reports and recommendations for improved analysis / Clin. Chem 57:1376~1386
Arase, K. / 1988 / Effect of fenfluramine on sympathetic firing rate / Pharmacol. Biochem. Behav 29:675~680
Bertrand, R. L. / 2011 / A Western diet increases serotonin availability in rat small intestine / Endocrinology 152:36~47
Bouwknecht, J. A. / 2001 / Male and female 5-HT(1B)receptor knockout mice have higher body weights than wildtypes / Physiol. Behav 74:507~516
Brand, T. / 2011 / The measurement of plateletpoor plasma serotonin : a systematic review of prior reports and recommendations for improved analysis / Clin. Chem 57:1376~1386
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