지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 1,071 - 1,078 (8page)
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초록· 키워드
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Superovulation induced by exogenous gonadotropin treatment (PMSG/hCG) increases the number of available oocytes in humans and animals. However, Superovulatory PMSG/hCG treatment is known to affect maternal environment, and these effects may result from PMSG/hCG treatment- induced oxidative stress. 2-Cys peroxiredoxins (2-Cys Prxs) act as antioxidant enzymes that protect cells from oxidative stress induced by various exogenous stimuli.
Therefore, the objective of this study was to test the hypothesis that repeated PMSG/hCG treatment induces 2-Cys Prx expression and overoxidation in the reproductive tracts of female mice. Immunohistochemistry and western blotting analyses further demonstrated that, after PMSG/hCG treatment, the protein expression levels of 2-Cys Prxs increased most significantly in the ovaries, while that of Prx1 was most affected by PMSG/hCG stimulation in all tissues of the female reproductive tract. Repeated PMSG/hCG treatment eventually leads to 2-Cys Prxs overoxidation in all reproductive organs of female mice, and the abundance of the 2-Cys Prxs-SO2/3 proteins reported here supports the hypothesis that repeated superovulation induces strong oxidative stress and damage to the female reproductive tract. Our data suggest that excessive oxidative stress caused by repeated PMSG/hCG stimulation increases 2-Cys Prxs expression and overoxidation in the female reproductive organs.
Intracellular 2-Cys Prx therefore plays an important role in maintaining the reproductive organ environment of female mice upon exogenous gonadotropin treatment.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Bae, S. H. / 2012 / Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury. Antioxid Redox / Signal 17:1351~1361
Bainbridge, D. R. / 1998 / Premature luteal regression induced by equine chorionic gonadotropin and estrogen is suppressed by administration of exogenous interferon in red deer(Cervus elaphus) / Biol. Reprod 58:124~129
Byers, S. L. / 2012 / Mouse estrous cycle identification tool and images / PLoS One 7:35538
Chae, H. Z. / 2012 / Protein glutathionylation in the regulation of peroxiredoxins : a family of thiol-specific peroxidases that function as antioxidants, molecular chaperones, and signal modulators / Antioxid Redox. Signal 16:506~523
Chao, H. T. / 2005 / Repeated ovarian stimulations induce oxidative damage and mitochondrial DNA mutations in mouse ovaries / Ann. N Y Acad. Sci 1042:148~156
Bainbridge, D. R. / 1998 / Premature luteal regression induced by equine chorionic gonadotropin and estrogen is suppressed by administration of exogenous interferon in red deer(Cervus elaphus) / Biol. Reprod 58:124~129
Byers, S. L. / 2012 / Mouse estrous cycle identification tool and images / PLoS One 7:35538
Chae, H. Z. / 2012 / Protein glutathionylation in the regulation of peroxiredoxins : a family of thiol-specific peroxidases that function as antioxidants, molecular chaperones, and signal modulators / Antioxid Redox. Signal 16:506~523
Chao, H. T. / 2005 / Repeated ovarian stimulations induce oxidative damage and mitochondrial DNA mutations in mouse ovaries / Ann. N Y Acad. Sci 1042:148~156
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