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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 1,105 - 1,110 (6page)
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Phleichrome, a pigment produced by the phytopathogenic fungus Cladosporium phlei, is a fungal perylenequinone whose photodynamic activity has been studied intensively.
To determine the biological function of phleichrome and to engineer a strain with enhanced production of phleichrome, we identified the gene responsible for the synthesis of phleichrome. Structural comparison of phleichrome with other fungal perylenequinones suggested that phleichrome is synthesized via polyketide pathway. We recently identified four different polyketide synthase (PKS) genes encompassing three major clades of fungal PKSs that differ with respect to reducing conditions for the polyketide product. Based on in silico analysis of cloned genes, we hypothesized that the non-reducing PKS gene, Cppks1, is involved in phleichrome biosynthesis. Increased accumulation of Cppks1 transcript was observed in response to supplementation with the application of synthetic inducer cyclo-(L-Pro-L-Phe). In addition, heterologous expression of the Cppks1 gene in Cryphonectria parasitica resulted in the production of phleichrome. These results provide convincing evidence that the Cppks1 gene is responsible for the biosynthesis of phleichrome.
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참고문헌 (38)
참고문헌 신청
Arnone, A. / 1985 / Secondary mould metabolites. Part 13. Fungal Perylenequinones: phleichrome, isophleichrome, and their endoperoxides / J. Chem. Soc. Perkin Trans I:1387~1392
Baek, J. H. / 2014 / Functional analysis of a tannic-acid-inducible and hypoviral-regulated small heat-shock protein Hsp24 from the chestnut blight fungus Cryphonectria parasitica / Mol. Plant Microbe Interact 27:56~65
Chen, R. E. / 2007 / Function and regulation in MAPK signaling pathways : lessons learned from the yeast Saccharomyces cerevisiae / Biochim. Biophys. Acta 1773:1311~1340
Choi, G. H. / 1990 / Nucleotide sequence of the glyceraldehyde-3-phosphate dehydrogenase gene from Cryphonectria parasitica / Nucleic Acids Res 18:5566
Choquer, M. / 2005 / The CTB1 gene encoding a fungal polyketide synthase is required for cercosporin biosynthesis and fungal virulence of Cercospora nicotianae / Mol. Plant Microbe Interact 18:468~476
Baek, J. H. / 2014 / Functional analysis of a tannic-acid-inducible and hypoviral-regulated small heat-shock protein Hsp24 from the chestnut blight fungus Cryphonectria parasitica / Mol. Plant Microbe Interact 27:56~65
Chen, R. E. / 2007 / Function and regulation in MAPK signaling pathways : lessons learned from the yeast Saccharomyces cerevisiae / Biochim. Biophys. Acta 1773:1311~1340
Choi, G. H. / 1990 / Nucleotide sequence of the glyceraldehyde-3-phosphate dehydrogenase gene from Cryphonectria parasitica / Nucleic Acids Res 18:5566
Choquer, M. / 2005 / The CTB1 gene encoding a fungal polyketide synthase is required for cercosporin biosynthesis and fungal virulence of Cercospora nicotianae / Mol. Plant Microbe Interact 18:468~476
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