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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 6 - 19 (14page)
- DOI
- 10.14348/molcells.2016.2323
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초록· 키워드
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Redox signalling comprises the biology of molecular signal transduction mediated by reactive oxygen (or nitrogen) species. By specific and reversible oxidation of redoxsensitive cysteines, many biological processes sense and respond to signals from the intracellular redox environment. Redox signals are therefore important regulators of cellular homeostasis. Recently, it has become apparent that the cellular redox state oscillates in vivo and in vitro, with a period of about one day (circadian). Circadian timekeeping allows cells and organisms to adapt their biology to resonate with the 24-hour cycle of day/night. The importance of this innate biological timekeeping is illustrated by the association of clock disruption with the early onset of several diseases (e.g. type II diabetes, stroke and several forms of cancer). Circadian regulation of cellular redox balance suggests potentially two distinct roles for redox signalling in relation to the cellular clock: one where it is regulated by the clock, and one where it regulates the clock. Here, we introduce the concepts of redox signalling and cellular timekeeping, and then critically appraise the evidence for the reciprocal regulation between cellular redox state and the circadian clock. We conclude there is a substantial body of evidence supporting circadian regulation of cellular redox state, but that it would be premature to conclude that the converse is also true. We therefore propose some approaches that might yield more insight into redox control of cellular timekeeping.
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참고문헌 (158)
참고문헌 신청
Abate, C. / 1990 / Redox regulation of fos and jun DNA-binding activity in vitro / Science 249:1157~1161
Anea, C. B. / 2013 / Circadian clock control of Nox4 and reactive oxygen species in the vasculature / PLoS One 8:78626
Aon, M. a. / 2003 / Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes / J. Biol. Chem 278:44735~44744
Asher, G. / 2011 / Crosstalk between components of circadian and metabolic cycles in mammals / Cell Metab 13:125~137
Asher, G. / 2008 / SIRT1 regulates circadian clock gene expression through PER2deacetylation / Cell 134:317~328
Anea, C. B. / 2013 / Circadian clock control of Nox4 and reactive oxygen species in the vasculature / PLoS One 8:78626
Aon, M. a. / 2003 / Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes / J. Biol. Chem 278:44735~44744
Asher, G. / 2011 / Crosstalk between components of circadian and metabolic cycles in mammals / Cell Metab 13:125~137
Asher, G. / 2008 / SIRT1 regulates circadian clock gene expression through PER2deacetylation / Cell 134:317~328
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