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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.3
- 수록면
- 195 - 203 (9page)
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Copper is an essential element required for a variety of functions exerted by cuproproteins. An alteration of the copper level is associated with multiple pathological conditions including chronic ischemia, atherosclerosis and cancers. Therefore, copper homeostasis, maintained by a combination of two copper ions (Cu+ and Cu2+), is critical for health. However, less is known about which of the two copper ions is more toxic or functional in endothelial cells. Cubic-shaped Cu2O and CuO crystals were prepared to test the role of the two different ions, Cu+ and Cu2+, respectively. The Cu2O crystal was found to have an effect on cell death in endothelial cells whereas CuO had no effect. The Cu2O crystals appeared to induce p62 degradation, LC3 processing and an elevation of LC3 puncta, important processes for autophagy, but had no effect on apoptosis and necrosis. Cu2O crystals promote endothelial cell death via autophagy, elevate the level of reactive oxygen species such as superoxide and nitric oxide, and subsequently activate AMP-activated protein kinase (AMPK) through superoxide rather than nitric oxide. Consistently, the AMPK inhibitor Compound C was found to inhibit Cu2O-induced AMPK activation, p62 degradation, and LC3 pro-cessing. This study provides insight on the pathophysio-logic function of Cu+ ions in the vascular system, where Cu+ induces autophagy while Cu2+ has no detected effect.
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참고문헌 (39)
참고문헌 신청
Abello, P. A. / 1994 / Antioxidants modulate induction of programmed endothelial cell death(apoptosis)by endotoxin / Arch. Surg 129:134~140
안세영 / 2014 / Transient Receptor Potential Cation Channel V1 (TRPV1) Is Degraded by Starvation- and Glucocorticoid-Mediated Autophagy / Molecules and Cells 37(3):257~263
Altekin, E. / 2005 / The relationship between trace elements and cardiac markers in acute coronary syndromes / J. Trace Elem. Med. Biol 18:235~242
Bar-Or, D. / 2001 / An analog of the human albumin N-terminus(Asp-Ala-His-Lys)prevents formation of copper-induced reactive oxygen species / Biochem. Biophys. Res. Commun 284:856~862
Barbusiński, K. / 2009 / Fenton reaction-controversy concerning the chemistry / Ecol. Chem. Eng. S 16:347~358
안세영 / 2014 / Transient Receptor Potential Cation Channel V1 (TRPV1) Is Degraded by Starvation- and Glucocorticoid-Mediated Autophagy / Molecules and Cells 37(3):257~263
Altekin, E. / 2005 / The relationship between trace elements and cardiac markers in acute coronary syndromes / J. Trace Elem. Med. Biol 18:235~242
Bar-Or, D. / 2001 / An analog of the human albumin N-terminus(Asp-Ala-His-Lys)prevents formation of copper-induced reactive oxygen species / Biochem. Biophys. Res. Commun 284:856~862
Barbusiński, K. / 2009 / Fenton reaction-controversy concerning the chemistry / Ecol. Chem. Eng. S 16:347~358
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