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논문 기본 정보

자료유형
학술저널
저자정보
Heonyong Park (Dankook University) Youngsik Seo (Dankook University) Young-Sik Cho (Dankook University) Young-Duk Huh (Dankook University)
저널정보
한국분자세포생물학회 Molecules and Cells Molecules and Cells 제39권 제3호
발행연도
2016.3
수록면
195 - 203 (9page)

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초록· 키워드

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Copper is an essential element required for a variety of functions exerted by cuproproteins. An alteration of the copper level is associated with multiple pathological conditions including chronic ischemia, atherosclerosis and cancers. Therefore, copper homeostasis, maintained by a combination of two copper ions (Cu+ and Cu2+), is critical for health. However, less is known about which of the two copper ions is more toxic or functional in endothelial cells. Cubic-shaped Cu2O and CuO crystals were prepared to test the role of the two different ions, Cu+ and Cu2+, respectively. The Cu2O crystal was found to have an effect on cell death in endothelial cells whereas CuO had no effect. The Cu2O crystals appeared to induce p62 degradation, LC3 processing and an elevation of LC3 puncta, important processes for autophagy, but had no effect on apoptosis and necrosis. Cu2O crystals promote endothelial cell death via autophagy, elevate the level of reactive oxygen species such as superoxide and nitric oxide, and subsequently activate AMP-activated protein kinase (AMPK) through superoxide rather than nitric oxide. Consistently, the AMPK inhibitor Compound C was found to inhibit Cu2O-induced AMPK activation, p62 degradation, and LC3 pro-cessing. This study provides insight on the pathophysio-logic function of Cu+ ions in the vascular system, where Cu+ induces autophagy while Cu2+ has no detected effect.

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