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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제42권 제5호
- 발행연도
- 2012.10
- 수록면
- 279 - 283 (5page)
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초록· 키워드
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The aim of this study was to compare physicochemical properties of solid lipid nanoparticles (SLN) made from different lipids. To make small, stable, uniform and highly encapsulated SLNs, many factors such as the components (lipid, stabilizer) and preparation condition (sonication time, power) can be considered. Out of those, we selected solid lipid as lipid matrix to investigate an effect on SLNs. The SLNs were characterized by particle size, zeta potential, solubility and in vitro release study. In this study,SLNs showed different physicochemical properties and release profiles according to used solid lipid. In case of particle size, M-SLN showed biggest particle size (412.5 ± 29.4 nm) and highest encapsulation efficiency (61.2 ± 4.8 %). And, B-SLN showed highest cumulative drug percentage (85.0 ± 1.7 %, 24 h) in release study.
These results suggest that lipids type affect physicochemical properties and release profile of SLN.
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참고문헌 (22)
참고문헌 신청
Anderson M / 2004 / The effect of different lipid componentson the in vitro stability and release kinetics of liposomeformulations / Drug Deliv 11(1):33~39
Carbone C / 2012 / Preparation and optimization of PIT solid lipid nanoparticles viastatistical factorial design / Eur J Med Chem 49:110~117
Ghadiri M / 2012 / Loading hydrophilic drug in solid lipidmedia as nanoparticles : statistical modeling of entrapmentefficiency and particle size / Int J Pharm 424(1):128~137
HuFQ JiangSP / 2005 / Preparation and characterization ofstearic acid nanostructured lipid carriers by solvent diffusionmethod in an aqueous system / Colloids Surf B Biointerfaces 45:167~173
Hurst SJ / 2006 / Maximizing DNAloading on a range of gold nanoparticle sizes / Anal Chem 78(24):13~18
Carbone C / 2012 / Preparation and optimization of PIT solid lipid nanoparticles viastatistical factorial design / Eur J Med Chem 49:110~117
Ghadiri M / 2012 / Loading hydrophilic drug in solid lipidmedia as nanoparticles : statistical modeling of entrapmentefficiency and particle size / Int J Pharm 424(1):128~137
HuFQ JiangSP / 2005 / Preparation and characterization ofstearic acid nanostructured lipid carriers by solvent diffusionmethod in an aqueous system / Colloids Surf B Biointerfaces 45:167~173
Hurst SJ / 2006 / Maximizing DNAloading on a range of gold nanoparticle sizes / Anal Chem 78(24):13~18
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