Adhesions are one of the most complications of surgery, and the leading cause of infertility, chronical pain and potentially intestinal obstruction. As the frequency of operation increases, prevention of adhesion formation has become a task to overcome in surgical research. A number of adjuvant have been investigated, including both pharmaceutical agents and physical barriers for adhesion prevention. Pharmaceutical agents and adhesion barrier have reduced adhesion formation in clinical practices to certain degrees, however, complete prevention of adhesions has yet to be overcome. In this review, the anti-adhesion agents were categorized into their uses and described of the properties of products commercially available. The purpose of this article is to review the current state of adhesion development and the effects of adhesion agents in prevention of adhesions.