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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 222 - 227 (6page)
- DOI
- 10.1186/s40824-016-0083-1
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초록· 키워드
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Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nanoparticles have been used to deliver hydrophobic drugs to the lymphatic pathway. This review focuses on the liposomal delivery systems used for intestinal lymphatic drug transport. Liposomal formulations have attracted particular attention because they can stimulate the production of chylomicrons and the incorporated drugs readily associate with enterocytederived chylomicrons, enhancing lymphatic drug transport. We believe that a full understanding of their contribution to intestinal drug translocation will lead to effective oral delivery with liposomal formulations.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Goldberg M / 2003 / Challenges for the oral delivery of macromolecules / Nat Rev Drug Disc 2:289~295
Charman WNA / 1986 / Estimating the maximum potential for intestinal lymphatic transport of lipophilic drug molecules / Int J Pharm 34:175~178
Porter CJH / 2007 / Lipids and lipid-based formulations : optimizing the oral delivery of lipophilic drugs / Nat Rev Drug Disc 6:231~248
Ali Khan A / 2013 / Advanced drug delivery to the lymphatic system : lipid-based nanoformulations / Int J Nanomedicine 8:2733~2744
Wasan KM / 2008 / Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs : implications for drug discovery / Nat Rev Drug Disc 7:84~99
Charman WNA / 1986 / Estimating the maximum potential for intestinal lymphatic transport of lipophilic drug molecules / Int J Pharm 34:175~178
Porter CJH / 2007 / Lipids and lipid-based formulations : optimizing the oral delivery of lipophilic drugs / Nat Rev Drug Disc 6:231~248
Ali Khan A / 2013 / Advanced drug delivery to the lymphatic system : lipid-based nanoformulations / Int J Nanomedicine 8:2733~2744
Wasan KM / 2008 / Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs : implications for drug discovery / Nat Rev Drug Disc 7:84~99
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