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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 209 - 215 (7page)
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Chlorhexidine has long been used in mouth washes for the control of dental caries, gingivitis and dental plaque.
Minimal inhibitory concentration (MIC) is the lowest concentration of an antimicrobial substance to inhibit the growth of bacteria. Concentrations lower than the MIC are called sub minimal inhibitory concentrations (sub-MICs).
Many studies have reported that sub-MICs of antimicrobial substances can affect the virulence of bacteria. The aim of this study was to investigate the effect of sub-MIC chlorhexidine on biofilm formation and coaggregation of oral early colonizers, such as Streptococcus gordonii, Actinomyces naeslundii and Actinomyces odontolyticus. The biofilm formation of S. gordonii, A. naeslundii and A.
odontolyticus was not affected by sub-MIC chlorhexidine.
However, the biofilm formation of S. mutans increased after incubation with sub-MIC chlorhexidine. In addition, cell surface hydrophobicity of S. mutans treated with sub-MIC of chlorhexidine, decreased when compared with the group not treated with chlorhexidine. However, significant differences were seen with other bacteria. Coaggregation of A.
naeslundii with A. odontolyticus reduced by sub-MIC chlorhexidine, whereas the coaggreagation of A. naeslundii with S. gordonii remained unaffected. These results indicate that sub-MIC chlorhexidine could influence the binding properties, such as biofilm formation, hydrophobicity and coaggregation, in early colonizing streptococci and actinomycetes.
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참고문헌 (36)
참고문헌 신청
Addy M / 1992 / Wade WG. The formation and control of dental plaque--an overview / J Appl Bacteriol 73:269~278
Braga PC / 2000 / Sub-MIC concentrations of cefodizime interfere with various factors affecting bacterial virulence / J Antimicrob Chemother 45:15~25
Lorian V / 1993 / Medical relevance of low concentrations of antibiotics / J Antimicrob Chemother 31(Suppl D):137~148
A. P. Fonseca / 2004 / Effect of subinhibitory concentration of piperacillin/tazobactam on Pseudomonas aeruginosa / Journal of Medical Microbiology 53(9):903~910
Lorian V / 1975 / Abnormal forms of bacteria produced by antibiotics / Am J Clin Pathol 64:678~688
Braga PC / 2000 / Sub-MIC concentrations of cefodizime interfere with various factors affecting bacterial virulence / J Antimicrob Chemother 45:15~25
Lorian V / 1993 / Medical relevance of low concentrations of antibiotics / J Antimicrob Chemother 31(Suppl D):137~148
A. P. Fonseca / 2004 / Effect of subinhibitory concentration of piperacillin/tazobactam on Pseudomonas aeruginosa / Journal of Medical Microbiology 53(9):903~910
Lorian V / 1975 / Abnormal forms of bacteria produced by antibiotics / Am J Clin Pathol 64:678~688
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