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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 225 - 230 (6page)
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초록· 키워드
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Inflammation from chronic and acute infections of distal organs and tissues such as periodontitis is a risk factor for atherosclerotic vascular processes. Recently, a new model of atherosclerosis with vascular pathologies was developed in the Mongolian gerbil. In this study, we attempted to develop a model of ligature-induced periodontitis in gerbils and compared the characteristics of that periodontitis model with that in rats and mice. Each gerbil, rat, and mouse was randomly assigned to groups of control and periodontitis. A thread was placed around the cervix of the right and left first molars in the mandible with knots placed on the mesial side of each molar.
At day 14 after the ligation, the animals were sacrificed and their mandibles were dissected. To measure alveolar bone loss along with inflammation, histopathological and micro-CT analyses were carried out. Gerbils showed tooth characteristics of deeper gingival crevice, longer cusp, longer root trunk and shorter root than those of rats and mice. The increased CEJ-ABC distance in distal and PDL area in furcation was also observed in ligated gerbils. An inflammatory response in the connective tissue under the junctional epithelium was also shown in all the animals. As a result, we confirmed the induction of periodontitis by ligature in the gerbils. We therefore consider the gerbil to be a useful model for investigating relationship between periodontitis and vascular disease in the same animal.
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참고문헌 (22)
참고문헌 신청
Xavier Struillou / 2010 / Experimental animal models in periodontology: a review / The Open Dentistry Journal 4(1):33~47
Oz HS / 2011 / Animal models for periodontal disease / J Biomed Biotechnol 2011:754857
Toshiharu Abe / 2013 / Optimization of the ligature-induced periodontitis model in mice / Journal of Immunological Methods 394(1-2):49~54
Poliana Mendes Duarte / 2010 / Microbial profile of ligature-induced periodontitis in rats / Archives of Oral Biology 55(2):142~147
Roivainen M / 2000 / Infections, inflammation, and the risk of coronary heart disease / Circulation 101:252~257
Oz HS / 2011 / Animal models for periodontal disease / J Biomed Biotechnol 2011:754857
Toshiharu Abe / 2013 / Optimization of the ligature-induced periodontitis model in mice / Journal of Immunological Methods 394(1-2):49~54
Poliana Mendes Duarte / 2010 / Microbial profile of ligature-induced periodontitis in rats / Archives of Oral Biology 55(2):142~147
Roivainen M / 2000 / Infections, inflammation, and the risk of coronary heart disease / Circulation 101:252~257
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