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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 55 - 65 (11page)
이용수
초록· 키워드
Objectives: Mibyeong is a korea medicine have original concept of the disease. However, no previous report has effect of mibyeong herbal medicine in fatigue types of mibyeong. This study investigated the question of whether Dang Gui Bo Hyul-tang(DGBHT) of effect on fatigue types of Mibyeong.
Methods: C57BL/6 mice were randomaly divided into three group (n=10). The mice were then group (1) Nocontrol, (2) Restraunt stress(veh), (3) Dang Gui Bo Hyul-tang 200mg/kg. The administered Dang Gui Bo Hyul-tang 200mg/kg or distilled water (orally) 1 hr prior to daily exposure to repeated restraint stress (2 h) for 15 days. The performed behavior test ( Mechanical hyperalgesia test,, Open-field test, Forced swimming test, Sucrose preference test and immunostaining and biochemical measured in serum.
Results: Stress fatigue induced mices significantly increased lethargic, hyperalgesia through behavior test ( Mechanical hyperalgesia test (decrease 43%), Open-field test (4,809± 226.13 ㎝ vs. 3121 ± 226.64 ㎝), Forced s wi m mi n g t e s t (11.45 ± 3.96 vs. 79.10 ± 8.12 sec), Sucrose preference test (decrease 58%)). In addition, chronic fatigue model evidently increased corticosterone level (122.54±18.88 vs. 186.94±18.26 ng/ml), AST level (46.22±3.23 vs.31.40±3.86 U/L), ALT level (38.78±5.72 vs. 17.60±1.30), liver necrosis, lateral ventricle size. These alterations were significantly ameliorated by DGBHT. DGBHT significantly attend the elevated serum concentrations of corticosterone (155.90±6.29 ng/ml), AST (31.40±3.86 U/L), ALT (17.60±1.30 U/L). Moreover, DGBHT improved lethargic, hyperalgesia when compared the stress fatigue ( Mechanical hyperalgesia test (improve 28%), Open-field test (4,038 ± 615.81 cm), Forced swimming test (7.56 ± 1.88 sec), Sucrose preference test (increase 21%) Conclusions: Theses result suggest that DGBHT have improved lethargic, hyperalgesia and fatigue-associated hormone and liver protective on stress fatigue model. It will be necessary to research to present evidences on benefits and effects of Korean medical treatment for Mibyeong through clinical researches based on benefits and effects of those animal models.
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