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자료유형
학술저널
저자정보
조영아 (성균관대학교 삼성서울병원 정신건강의학교실) 유승형 (성균관대학교) 오혜지 (삼성생명과학연구소) 오소희 (보라매병원) 박태성 (서울대학교) 윤세창 (성균관대학교) 홍경수 (성균관대학교)
저널정보
대한조현병학회 대한조현병학회지 대한조현병학회지 제17권 제2호
발행연도
2014.10
수록면
72 - 79 (8page)
DOI
http://dx.doi.org/10.16946/kjsr.2014.17.2.72

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Objectives : Considering large diversity of clinical presentation of schizophrenia, it is important to identify valid clinical subtypes or dimensions that might have homogeneous biological underpinning. The current study aimed to explore lifetime symptom-based dimensional phenotypes in patients with chronic schizophrenia, and to investigate their correlation with cognitive functions and other clinical characteristics. Methods : Lifetime-based symptoms and additional clinical variables were measured using the Diagnostic Interview for Genetic Studies and the Schedule for the Deficit Syndrome in 315 clinically stable patients with chronic schizophrenia. Through principal components factor analysis, eight dimensional phenotypes were obtained. Comprehensive neuropsychological tests were administered for 103 out of 315 patients, and domain scores were calculated for cognitive domains defined in the MATRICS consensus battery. Results : ‘Non-paranoid delusion factor’ including delusions of grandiose or religious nature, showed significant negative correlation with processing speed, working memory, attention/vigilance, and general cognitive ability, and positive correlation with intra-individual variability. ‘Negative symptom factor’ showed significant negative correlation only with general cognitive ability. Those two factors were also negatively correlated with function levels measured by Global Assessment Scale (GAS), and associated with poor treatment responses. Conclusion : Symptom-based dimensional phenotypes of schizophrenia measured on a lifetime basis showed discriminative correlation with cognitive function domains, global functioning level, and overall treatment responses, indicating their possibility as valid phenotype axes of schizophrenia having homogeneous biologic basis.

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