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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Flexibilities in protein conformations are essential for their functions, playing key roles in molecular recognition, ratelimitingconformational transitions, and catalysis. Information on the structure of proteins should be complemented bythe information on their motion, both to characterize the protein and to understand its function. The relationship betweenprotein structure, dynamics, and function is very challenging to study because the conformational space available to aprotein is extensive and the time scales of conformational motions range widely, from picoseconds to seconds. Thesetime scales are accessible by solution NMR making it a suitable technique for investigating the motions in proteins. In thisreview, an introduction to NMR spin relaxation approaches is provided to investigate protein dynamics on picosecondto-second time scales, showing the recent NMR techniques as well as case studies on protein motions. The importanceof dynamic features of proteins for their molecular recognition processes and the catalytic activities of enzymes isdemonstrated using spin relaxation approaches, showing that solution NMR spectroscopy is a unique tool for studyingprotein dynamics.
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참고문헌 (27)
참고문헌 신청
Abragam, A. / 1961 / Principles of nuclear magnetism / Clarendon Press
Al-Aidaroos, A. Q. / 2010 / PRL-3 phosphatase and cancer metastasis / J Cell Biochem 111:1087~1098
Boehr, D. D. / 2006 / An NMR perspective on Enzyme Dynamics / Chem Rev 106:3055~3079
Brüschweiler, R. / 2003 / New approaches to the dynamic interpretation and prediction of NMR relaxation data from proteins / Current Opinion in Structural Biology 13:175~183
Clore, G. M. / 1990 / Deviations from the simple two-parameter model-free approach to the interpretation of nitrogen-15 nuclear magnetic relaxation of proteins / J Am Chem Soc 112:4989~4991
Al-Aidaroos, A. Q. / 2010 / PRL-3 phosphatase and cancer metastasis / J Cell Biochem 111:1087~1098
Boehr, D. D. / 2006 / An NMR perspective on Enzyme Dynamics / Chem Rev 106:3055~3079
Brüschweiler, R. / 2003 / New approaches to the dynamic interpretation and prediction of NMR relaxation data from proteins / Current Opinion in Structural Biology 13:175~183
Clore, G. M. / 1990 / Deviations from the simple two-parameter model-free approach to the interpretation of nitrogen-15 nuclear magnetic relaxation of proteins / J Am Chem Soc 112:4989~4991
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