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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 1 - 15 (15page)
- DOI
- 10.1186/s40580-016-0083-9
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초록· 키워드
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Current stem cell therapy suffers low efficiency in giving rise to differentiated cell lineages, which can replace the original damaged cells. Nanomaterials, on the other hand, provide unique physical size, surface chemistry, conductivity, and topographical microenvironment to regulate stem cell differentiation through multidimensional approaches to facilitate gene delivery, cell?cell, and cell?ECM interactions. In this review, nanomaterials are demonstrated to work both alone and synergistically to guide selective stem cell differentiation. From three different nanotechnology families, three approaches are shown: (1) soluble microenvironmental factors; (2) insoluble physical microenvironment; and (3) nano-topographical features. As regenerative medicine is heavily invested in effective stem cell therapy, this review is inspired to generate discussions in the potential clinical applications of multi-dimensional nanomaterials.
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참고문헌 (73)
참고문헌 신청
C. H. Wang / 2008 / Drawbacks to stem cell therapy in cardiovascular diseases / Future Cardiol 4:399~408
S. P. Medvedev / 2010 / Induced pluripotent stem cells: problems and advantages when applying them in regenerative medicine / Acta Nat 2:18~27
T. H. Kim / 2015 / Controlling differentiation of adipose-derived stem cells using combinatorial graphene hybrid-pattern arrays / ACS Nano 9:3780~3790
C. Liu / 2015 / The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells / Bone Res 3:15012
A. Solanki / 2008 / Nanotechnology for regenerative medicine:nanomaterials for stem cell imaging / Nanomedicine (Lond) 3:567~578
S. P. Medvedev / 2010 / Induced pluripotent stem cells: problems and advantages when applying them in regenerative medicine / Acta Nat 2:18~27
T. H. Kim / 2015 / Controlling differentiation of adipose-derived stem cells using combinatorial graphene hybrid-pattern arrays / ACS Nano 9:3780~3790
C. Liu / 2015 / The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells / Bone Res 3:15012
A. Solanki / 2008 / Nanotechnology for regenerative medicine:nanomaterials for stem cell imaging / Nanomedicine (Lond) 3:567~578
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