지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 159 - 164 (6page)
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초록· 키워드
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Purpose: Enteroviruses (EV) have been known as one of the important pathogens of aseptic meningitis in pediatrics. Clinical manifestations include asymptomatic cases to serious neurologic sequlaes. This study aimed to describe an overview of the seasonality, laboratory, and clinical characteristics of enteroviral meningitis in pediatric patients over a 7-year period.
Methods: We performed a retrospective medical record review of patients with a positive cerebrospinal fluid (CSF) enterovirus polymerase chain reaction (PCR) result in the pediatric department of Chung-Ang University Hospital between January 2008 and December 2014. Patients were subsequently divided into ≤1-year age group and >1 year age group.
Results: Of 302 patients with aseptic meningitis, 121 were diagnosed with enteroviral meningitis. There were 25 patients in the ≤1-year age group. Patients were detected throughout all four seasons but were more prevalent in the summer months, especially July. Patients in the ≤1-year age group had more seizures (P=0.034) and rashes (P=0.001), but fewer gastrointestinal symptoms (P=0.001) than patients in the >1-year age group.No significant difference was found between the two groups in terms of total white blood cell count and CSF analysis.
Conclusion: There is prominent summer seasonality for enteroviral meningitis detections. Seizures were more common in the ≤1-year age group. The combination of information from epidemiologic, clinical, and laboratory findings are necessary to facilitate the diagnosis of enteroviral meningitis. Infants often do not exhibit the common signs of enteroviral meningitis, and are at an increased risk for seizure; therefore, physicians should pay particular attention to this population.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Norder H / 2003 / Sequencing of 'untypable' enteroviruses reveals two new types, EV-77 and EV-78, within human enterovirus type B and substitutions in the BC loop of the VP1 protein for known types / J Gen Virol 84:827~836
Oberste M / 2001 / Molecular identification of new picornaviruses and characterization of a proposed enterovirus 73 serotype / J Gen Virol 82:409~416
Cinek O / 2006 / Longitudinal observation of enterovirus and adenovirus in stool samples from Norwegian infants with the highest genetic risk of type 1 diabetes / J Clin Virol 35:33~40
Tebruegge M / 2009 / Enterovirus infections in neonates / Semin Fetal Neonatal Med 14:222~227
Lum LC / 1998 / Neurogenic pulmonary oedema and enterovirus 71 encephalomyelitis / Lancet 352:1391
Oberste M / 2001 / Molecular identification of new picornaviruses and characterization of a proposed enterovirus 73 serotype / J Gen Virol 82:409~416
Cinek O / 2006 / Longitudinal observation of enterovirus and adenovirus in stool samples from Norwegian infants with the highest genetic risk of type 1 diabetes / J Clin Virol 35:33~40
Tebruegge M / 2009 / Enterovirus infections in neonates / Semin Fetal Neonatal Med 14:222~227
Lum LC / 1998 / Neurogenic pulmonary oedema and enterovirus 71 encephalomyelitis / Lancet 352:1391
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