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논문 기본 정보

자료유형
학술저널
저자정보
Huimin Liu (Henan Agricultural University) Li Yang (Henan Agricultural University) Zhibin Shi (Henan Agricultural University) Ruiqi Lv (Henan Agricultural University) Xia Yang (Henan Agricultural University) Chuanqing Wang (Henan Agricultural University) Lu Chen (Henan Agricultural University) Hongtao Chang (Henan Agricultural University)
저널정보
대한수의학회 Journal of Veterinary Science Journal of Veterinary Science 제20권 제6호
발행연도
2019.11
수록면
99 - 110 (12page)

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Viral-encoded microRNAs (miRNAs) have vital roles in the regulation of virus replications and host immune responses. The results of previous studies have indicated that miRNA clusters are involved in the replication and virulence of the pseudorabies virus (PRV), which may potentially lead to immune escape or facilitation of PRV replication. This study"s previous research revealed that prv-miR-LLT11a was differentially expressed during PRV infection. The present study"s results have demonstrated that prv-miR-LLT11a could significantly inhibit PRV replication. It was further determined that SLA-1 was the target gene of prv-miR-LLT11a, and simultaneously, that overexpression of prv-miR-LLT11a could downregulate the mRNA and protein levels of SLA-1 in a dose-independent manner. Furthermore, the present study also observed that prv-miR-LLT11a can downregulate TAP1 expression. Our findings provide a better understanding of the molecular mechanism involved in the effects of prv-miR-LLT11a on SLA-1 and TAP1 as well as its involvement in immune system evasion of PRV.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
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