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논문 기본 정보

자료유형
학술저널
저자정보
Limei Zhou (Institute for Clinical Evaluative Sciences (ICES)) Peter C. Austin (Institute for Clinical Evaluative Sciences (ICES)) Husam Abdel-Qadir (Institute for Clinical Evaluative Sciences (ICES))
저널정보
한국통계학회 CSAM(Communications for Statistical Applications and Methods) CSAM(Communications for Statistical Applications and Methods) 제30권 제1호
발행연도
2023.1
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1 - 19 (19page)

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초록· 키워드

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Observational data with missing or incomplete data are common in biomedical research. Multiple imputation is an effective approach to handle missing data with the ability to decrease bias while increasing statistical power and effciency. In recent years propensity score (PS) matching has been increasingly used in observational studies to estimate treatment effect as it can reduce confounding due to measured baseline covariates. In this paper, we describe in detail approaches to competing risk analysis in the setting of incomplete observational data when using PS matching. First, we used multiple imputation to impute several missing variables simultaneously, then conducted propensity-score matching to match statin-exposed patients with those unexposed. Afterwards, we assessed the effect of statin exposure on the risk of heart failure-related hospitalizations or emergency visits by estimating both relative and absolute effects. Collectively, we provided a general methodological framework to assess treatment effect in incomplete observational data. In addition, we presented a practical approach to produce overall cumulative incidence function (CIF) based on estimates from multiple imputed and PS-matched samples.

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Abstract
1. Introduction
2. Methodology
3. Statistical analysis
4. Results
5. Discussion
References

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