지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Raphanus sativus L. has been reported to have anti-inflammatory and anti-tumor activity. However, the anti-inflammatory effect and mechanism of action of the Raphanus sativus L. seeds (RSS) with or without oil are still unknown. This study was undertaken to investigate the in-vitro anti-inflammatory effect with or without oil in the RSS on RAW 264.7 cells stimulated by lipopolysaccharide (LPS). Results showed the suppressed LPS-induced secretion of pro-inflammatory mediators such as nitric oxide (NO), inflammatory cytokine (IL-6, TNF-α). Additionally, a decrease in protein expression of iNOS was observed, but nuclear translocation of NF-κB p65 was not inhibited. To elucidate the underlying mechanism of the antiinflammatory effect of RSS, the involvement of mitogen-activated protein kinase (MAPK) signaling pathways was examined. We also found that RSS blocked LPS-induced phosphorylation of c-Jun Nterminal kinase/stress-activated protein kinase (JNK) signaling but did not affect the phosphorylation of p38 MAPK and extracellular signal-regulated kinase (ERK) 1/2. These results suggest that RSS may have potential as an anti-inflammatory agent through the inhibition of LPS-induced inflammatory cytokine production via regulation of the JNK pathway.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
Result
Discussion
Reference
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
선학초(仙鶴草)추출물의 대식세포에서의 LPS-유도 염증반응에 대한 효능 연구
대한본초학회지(본초분과학회지)
2016 .01
-
JS-III-49, a hydroquinone derivative, exerts anti-inflammatory activity by targeting Akt and p38
The Korean Journal of Physiology & Pharmacology
2017 .05
-
Anti-inflammatory activities of sinensetin on LPS-stimulated L6 skeletal muscle cells
Journal of Biomedical and Translational Research
2019 .01
-
대두, 홍삼, 진피로 구성된 발효 추출물의 항염증 효능에 관한 연구
대한본초학회지(본초분과학회지)
2015 .01
-
Extract mulberry leaves fermented with Cordyceps militaris exerts anti inflammatory effects in LPS stimulated RAW264.7 macrophage cells by regulating COX-2/iNOS, inflammatory cytokine expression, MAP kinase pathways, the cell cycle and anti oxidant activity
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Suppression of Inflammatory Responses by Black Rice Extract in RAW 264.7 Macrophage Cells via Downregulation of NF-kB and AP-1 Signaling Pathways
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
백출에서 분리된 Atractylenolide Ⅱ의 RAW264.7 대식세포와 BV2 미세아교세포에서의 항염증 효과
생약학회지(Korean Journal of Pharmacognosy)
2020 .12
-
LPS로 유발한 RAW264.7 세포 염증반응에 대한 가감통순산(加減通順散)의 억제 효과
한방재활의학과학회지
2018 .01
-
Beneficial Therapy with Natural Anti-Inflammatory Agents and Supplements
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2021 .12
-
Anti-inflammatory Effects of Ethanol Extract of Various Korean Compositae Herbs in LPS-induced RAW 264.7 Macrophages
대한본초학회지(본초분과학회지)
2017 .01
-
BO2, an extract of mixed natural plants inhibits inflammatory responses in LPS-stimulated Raw 264.7 macrophages
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Anti-Inflammatory Effect of Rosa rugosa Flower Extract in Lipopolysaccharide-Stimulated RAW264.7 Macrophages
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
-
Anti-inflammatory Effect of Flower Bud and Fruit of Sweet Persimmon, Diospyros kaki T
대한의생명과학회지
2020 .06
-
해독금화산 물추출물이 LPS로 유도된 대식세포의 염증반응에 미치는 영향
대한본초학회지(본초분과학회지)
2015 .01
-
Anti-inflammatory Effects of Complex Extract including Eucommia ulmoides in LPS-induced RAW 264.7 Cells
대한침구의학회지
2019 .01
-
Lorafocin, a mixture of Eunkyosan and alginate attenuate LPS-induced inflammation in RAW264.7 cells and inhibit growth of infectious bacteria
셀메드
2024 .11
-
Anti-inflammatory Effects of Ethanol Extract of Korean Medicinal Plants at Hwaak Mountain in LPS-induced RAW 264.7 Macrophages
대한본초학회지(본초분과학회지)
2017 .01
-
5-Aminolevulinic acid nhibits lipopolysaccharide-induced inflammatory and oxidative reactions in RAW 264.7 macrophages and zebrafish larvae
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Exploration of targeted Anti-inflammatory drugs using LPS- or MDP-Induced inflammation models
한국실험동물학회 학술발표대회 논문집
2025 .02
-
LPS로 유도된 RAW 264.7 세포의 염증반응에서 감송향(甘松香)에서 추출한 8α-hydroxy pinoresinol의 항염증 효과
대한본초학회지(본초분과학회지)
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0