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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Analysis Health and Toxicology Vol.38 No.2
- 발행연도
- 2023.6
- 수록면
- 28 - 36 (9page)
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초록· 키워드
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Titanium dioxide (TiO₂) was used in various applications in a wide range of products including food, cosmetics and photocatalyst. General toxicity studies of titanium dioxide, GST (Green Sludge Titanium) have been investigated in several reports, whereas studies concerning mutagenicity and genotoxicity have not been elucidated. Herein, we investigated the potential mutagenicity and genotoxicity of GST by genetic toxicology testing. The bacterial reverse mutation test was conducted by the pre-incubation method in the presence and absence of metabolic activation system (S9 mixture). The chromosome aberration test was performed using cultured Chinese hamster lung cell line in the absence and presence of S9 mixture. The micronucleus test was performed by using specific pathogen-free male ICR mice. Genotoxicity tests were conducted following the test guidelines of the Organisation for Economic Cooperation and Development with application of Good Laboratory Practice. No statistically significant increases were found in the bacterial reverse mutation test, in vitro chromosome aberration test, and in vivo micronucleus test when tested for induction of genotoxicity in GST. These results suggest that GST did not induce mutagenicity and genotoxicity in both in vitro and in vivo system.
목차
Abstract
Introduction
Materials and Methods
Results and Discussion
Conclusions
References
참고문헌 (20)
참고문헌 신청
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Orlov A, Chan MS, Jefferson DA, Zhou D, Lynch RJ, Lambert RM. Photocatalytic degradation of water-soluble organic pollutants on TiO2 modified with gold nanoparticles. Environ Technol 2006;27(7):747-52. https://doi.org/10.1080/09593332708618685
Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, et al. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. https://doi.org/10.1186/1743-8977-2-8
Chen T, Yan J, Li Y. Genotoxicity of titanium dioxide nanoparticles. J Food Drug Anal 2014;22(1):95-104. https://doi.org/10.1016/j.jfda.2014.01.008
Organization for Economic Co-operation and Development (OECD). OECD Series on principle of good laboratory practice and compliance monitoring, No.1 (Revised): OECD Principles of Good Laboratory Practice, ENV/MC/CHEM(98)17. [cited Dec 1, 2021]. Available f
Orlov A, Chan MS, Jefferson DA, Zhou D, Lynch RJ, Lambert RM. Photocatalytic degradation of water-soluble organic pollutants on TiO2 modified with gold nanoparticles. Environ Technol 2006;27(7):747-52. https://doi.org/10.1080/09593332708618685
Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, et al. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. https://doi.org/10.1186/1743-8977-2-8
Chen T, Yan J, Li Y. Genotoxicity of titanium dioxide nanoparticles. J Food Drug Anal 2014;22(1):95-104. https://doi.org/10.1016/j.jfda.2014.01.008
Organization for Economic Co-operation and Development (OECD). OECD Series on principle of good laboratory practice and compliance monitoring, No.1 (Revised): OECD Principles of Good Laboratory Practice, ENV/MC/CHEM(98)17. [cited Dec 1, 2021]. Available f
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