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학술저널
저자정보
최홍상 (전남대학교병원) Kim Bongseong (Department of Statistics and Actuarial Science Soongsil University Seoul Korea.) Han Kyungdo (Department of Statistics and Actuarial Science College of Natural Sciences Soongsil University Seoul Korea.) 오태렴 (전남대학교병원) 서상헌 (전남대학교병원) 김민아 (전남대학교병원) 김창성 (전남대학교병원) 배은희 (전남대학교) 마성권 (전남대학교) 김수완 (전남대학교)
저널정보
대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.42 No.1
발행연도
2023.1
수록면
86 - 97 (12page)
DOI
10.23876/j.krcp.21.294

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Background: Several studies have reported that depression is prevalent in patients with diabetes or chronic kidney disease. However,the relationship between weight changes and the risk of depression has not been elucidated in patients with diabetic kidney disease(DKD).Methods: From the Korean National Health Insurance Service database, we selected 67,866 patients with DKD and body weightdata from two consecutive health examinations with a 2-year interval between 2009 and 2012. Weight change over 2 years was categorizedinto five groups: ≥–10%, <–10% to ≥–5%, <–5% to <5%, ≥5% to <10%, and ≥10%. The occurrence of depression was monitoredvia the codes of International Statistical Classification of Diseases, 10th revision through the end of 2018.Results: During the 5.24-year follow-up, 17,023 patients with DKD developed depression. Weight change and the risk of depressionhad a U-shaped relationship: patients with ≥–10% weight change (hazard ratio [HR], 1.12) and those with ≥10% weight change (HR,1.11) showed higher HRs for depression than those with <–5% to <5% weight change, even after adjusting for several confoundingfactors. In the subgroup analyses, the risk of depression tended to increase as weight gain or weight loss increased in all subgroups.Conclusion: Both weight loss and weight gain increased the risk of depression in patients with DKD.

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