A wound-friendly antibacterial hyaluronic acid dressing with on-demand removability for infected wound healing

Datao Hu; Jinpeng Wen; Xinxin Zhao; Kailai Liu; Yuchen Zhang; Yizhuo Bu; Ke Wang

doi:https://doi.org/10.1186/s40824-023-00340-7

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자료유형: 학술저널

저자정보: Datao Hu (School of Pharmacy Health Science Center Xi’an Jiaotong University) Jinpeng Wen (School of Pharmacy Health Science Center Xi’an Jiaotong University) Xinxin Zhao (School of Pharmacy Health Science Center Xi’an Jiaotong University) Kailai Liu (School of Pharmacy Health Science Center Xi’an Jiaotong University) Yuchen Zhang (School of Pharmacy Health Science Center Xi’an Jiaotong University) Yizhuo Bu (School of Pharmacy Health Science Center Xi’an Jiaotong University) Ke Wang (School of Pharmacy Health Science Center Xi’an Jiaotong University)

저널정보: 한국생체재료학회 생체재료학회지 생체재료학회지 제27권

발행연도: 2023.3

수록면: 1,076 - 1,092 (17page)

DOI: https://doi.org/10.1186/s40824-023-00340-7

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Background Antibacterial activity and on-demand removability are key characteristics governing the effectiveness of clinic wound dressing. However, the excellent tissue adhesion of new dressings is often overemphasized without a detailed discussion of dressing replacement. Besides, the inherent antibacterial ability of dressings is beneficial for promoting the healing of infected wound. Therefore, we rationally design an injectable antibacterial wound dressing with on-demand removability to accelerate infected wound healing. Method We design this wound dressing with a simple and feasible method based on the electrostatic self-assembly of hyaluronic acid and ε-polylysine. We investigated the efficacy of this dressing in terms of its microtopography, rheology, self-healing performance, adhesive ability, antimicrobial, hemostatic, on-demand removal properties, and wound healing promotion through various tests. Results The prepared dressing possesses injectability, self-healing ability and antibacterial activity, showing NaCl-triggered on-demand dissolution due to the disruption of electrostatic interactions. When used as dressings for healing full-thickness wounds, it could effectively accelerate wound healing by killing bacteria, downregulating inflammation, promoting collagen deposition, enhancing keratinocyte migration and angiogenesis due to its excellent adhesion ability, favorable hemostatic property, and potent antibacterial performance. Conclusion All results indicate that this is a simple and practical dressing for clinical application. This strategy provides a novel idea for developing on-demand removal dressings with antibacterial and injectable properties.

#On-demand removal #Injectable #Antibacterial #Wound dressing

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