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학술저널
저자정보
Ik Hyun Jo (Department of Internal Medicine St. Vincent’s Hospital College of Medicine The Catholic University of Korea Seoul Korea) Chang Nyol Paik (Department of Internal Medicine The Catholic University of Korea St. Vincent’s Hospital Suwon Korea) Yeon-Ji Kim (Department of Internal Medicine Nowon Eulji Medical Center Eulji University Seoul Korea) Ji Min Lee (Department of Internal Medicine St. Vincent’s Hospital College of Medicine The Catholic University of Korea Seoul Korea) Soo Yeon Choi (Department of Internal Medicine St. Vincent’s Hospital College of Medicine The Catholic University of Korea Seoul Korea) Kee Pyung Hong (Department of Internal Medicine St. Vincent’s Hospital College of Medicine The Catholic University of Korea Seoul Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.29 No.1
발행연도
2023.1
수록면
85 - 93 (9page)
DOI
10.5056/jnm22023

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Background/AimsLactase deficiency, which has many similarities with small intestinal bacterial overgrowth (SIBO), causes various gastrointestinal symptoms. We estimate the prevalence of SIBO in patients with intestinal symptoms from dairy products and investigate the association between lactase deficiency (LD) and SIBO.MethodsThis prospective study included patients with functional intestinal symptoms from dairy product indigestion. A questionnaire on gastrointestinal symptoms, a hydrogen (H2)-methane glucose breath test (GBT) for SIBO, and lactose intolerance quick test (LQT) for LD using upper gastrointestinal endoscopy were performed.ResultsA total of 88 patients, 29 (33.0%) with severe and 36 (40.9%) with mild LD were included. Sixteen patients (18.2%) were GBT positive. Patients with LQT negativity indicating severe LD showed a higher positivity to GBT or GBT (H2) than the historic controls (27.6% vs 6.7%, P = 0.032). There was no difference in the items on the symptom questionnaire according to the presence of LD or SIBO, except for higher symptom scores for urgency in GBT-positive patients. There were more LQT-negative patients in the GBT (H2)-positive group than in the other groups (27.6% vs 10.2%, P = 0.036). Moreover, only GBT (H2)-positivity was significantly associated with a higher risk of LQT negativity in multivariate analysis (OR, 4.19; P = 0.029).ConclusionsSIBO producing H2 is common in patients with severe LD suspected lactose intolerance. SIBO may be a new therapeutic target for managing intestinal symptoms in patients with lactose intolerance.

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