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논문 기본 정보

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저자정보
Kim Jihyun (Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences) Kim Byung Eui (Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.Department of Pediatrics National Jewish Health Denver CO USA.) Goleva Elena (Department of Pediatrics National Jewish Health Denver CO USA.) Berdyshev Evgeny (Department of Pediatrics National Jewish Health Denver CO USA.) 배재웅 (R&D Institute BioEleven Co. Ltd.) Kim Seokjin (R&D Institute BioEleven Co. Ltd. Seoul Korea) Kim Hye-young (Department of Pediatrics Medical Research Institute of Pusan National University Hospital Pusan National University School of Medicine Busan Korea.) Lee Un Ha (Department of Dermatology Sanggye Paik Hospital Inje University College of Medicine Seoul Korea.) Kim Myoung Shin (Department of Dermatology Sanggye Paik Hospital Inje University College of Medicine Seoul Korea.) Jung Minyoung (Department of Pediatrics Kosin University Gospel Hospital Kosin University College of Medicine Busan Korea.) Kim Hyunmi (Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.) Lee Jinyoung (Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.) Donald Y.M. Leung (Department of Pediatrics National Jewish Health Denver CO USA.) Ahn Kangmo (Department of Pediatrics Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.15 No.2
발행연도
2023.3
수록면
186 - 200 (15page)
DOI
10.4168/aair.2023.15.2.186

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Purpose: We aimed to investigate epidermal lipid profiles and their association with skin microbiome compositions in children with atopic dermatitis (AD). Methods: Specimens were obtained by skin tape stripping from 27 children with AD and 18 healthy subjects matched for age and sex. Proteins and lipids of stratum corneum samples from nonlesional and lesional skin of AD patients and normal subjects were quantified by liquid chromatography tandem mass spectrometry. Skin microbiome profiles were analyzed using bacterial 16S rRNA sequencing. Results: Ceramides with nonhydroxy fatty acids (FAs) and C18 sphingosine as their sphingoid base (C18-NS-CERs) N-acylated with C16, C18 and C22 FAs, sphingomyelin (SM) N-acylated with C18 FAs, and lysophosphatidylcholine (LPC) with C16 FAs were increased in AD lesional skin compared to those in AD nonlesional skin and that of control subjects (all P < 0.01). SMs N-acylated with C16 FAs were increased in AD lesional skin compared to control subjects (P < 0.05). The ratio of NS-CERs with long-chain fatty acids (LCFAs) to short-chain fatty acids (SCFAs) (C24-32:C14-22), the ratio of LPC with LCFAs to SCFAs (C24-30:C16-22) as well as the ratio of total esterified omega-hydroxy ceramides to total NS-CERs were negatively correlated with transepidermal water loss (rho coefficients = −0.738, −0.528, and −0.489, respectively; all P < 0.001). The proportions of Firmicutes and Staphylococcus were positively correlated to SCFAs including NS ceramides (C14-22), SMs (C17-18), and LPCs (C16), while the proportions of Actinobacteria, Proteobacteria, Bacteroidetes, Corynebacterium, Enhydrobacteria, and Micrococcus were negatively correlated to these SCFAs. Conclusions: Our results suggest that pediatric AD skin shows aberrant lipid profiles, and these alterations are associated with skin microbial dysbiosis and cutaneous barrier dysfunction.
#Atopic dermatitis #child #microbiota #Staphylococcus #ceramides #lipids #fatty acids

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