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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.13 No.2
- 발행연도
- 2023.5
- 수록면
- 175 - 183 (9page)
- DOI
- https://doi.org/10.1007/s13534-023-00264-0
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초록· 키워드
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Cell entosis is a novel cell death process starting from cell-in-cell invasion. In general, cancer cells own higher incidencerate of cell entosis comparing to non-cancerous cells. Studies arguing whether cell entosis is a tumor suppressing processor a tumor accelerating process can deepen our understanding of tumor development. Cell elasticity is recognized as one oftumor malignant biomarkers. There have been some researchers studying cell elasticity in cell entosis. However, existingcell elasticity sensing technique (i.e. micropipette aspiration) can hardly be reliable neither high-throughput. In this work, weintroduce an elasticity sensing method for quantifying both cell elasticity in cell-in-cell structures and single floating cellsusing a microfluidic cytometer. We not only argue our cell elasticity sensing method is reliable for already occurred entosisbut also apply such method on predicting the “outer” cells in entosis of different cell types. The elasticity sensing methodproposed in this manuscript is able to provide an effective and reliable way to further study deeper mechanism in cell entosis.
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