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학술저널
저자정보
Jae Hyun Kim (Asan Medical Center University of Ulsan College of Medicine) Hee-Won Jeong (Department of Neurosurgery Chungnam National University Hospital) Yoon-Hee Choo (Seoul St. Mary’s Hospital The Catholic University of Korea) Moinay Kim (Department of Neurological Surgery Asan Medical Center) Eun Jin Ha (Department of Critical Care Medicine Seoul National University Hospital Seoul Korea) Jiwoong Oh (Department of Neurosurgery Severance Hospital Yonsei University) Youngbo Shim (Department of Critical Care Medicine Kangbuk Samsung Hospital) Seung Bin Kim (Seoul Metropolitan Government-Seoul National University Boramae Medical Center) Han-Gil Jung (Department of Neurosurgery and Neurology Seoul National University Bundang Hospital) So Hee Park (Department of Neurosurgery College of Medicine Yeungnam University Daegu Korea) Jungook Kim (Gachon University Gil Hospital Regional Trauma Center) Junhyung Kim (Department of Neurosurgery Gangnam Severance Hospital Yonsei University College of Medicine Seoul Korea) Hye Seon Kim (Incheon St. Mary’s Hospital College of Medicine The Catholic University) Seungjoo Lee (Department of Neurological Surgery Asan Medical Center Korea)
저널정보
대한신경손상학회 Korean Journal of Neurotrauma Korean Journal of Neurotrauma Vol.19 No.2
발행연도
2023.6
수록면
162 - 176 (15page)
DOI
https://doi.org/10.13004/kjnt.2023.19.e25

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Mannitol, derived from mannose sugar, is crucial in treating patients with elevated intracranial pressure (ICP). Its dehydrating properties at the cellular and tissue levels increase plasma osmotic pressure, which is studied for its potential to reduce ICP through osmotic diuresis. While clinical guidelines support mannitol use in these cases, the best approach for its application continues to be debated. Important aspects needing further investigation include: 1) bolus administration versus continuous infusion, 2) ICP-based dosing versus scheduled bolus, 3) identifying the optimal infusion rate, 4) determining the appropriate dosage, 5) establishing fluid replacement plans for urinary loss, and 6) selecting monitoring techniques and thresholds to assess effectiveness and ensure safety. Due to the lack of adequate high-quality prospective research data, a comprehensive review of recent studies and clinical trials is crucial. This assessment aims to bridge the knowledge gap, improve understanding of effective mannitol use in elevated ICP patients, and provide insights for future research. In conclusion, this review aspires to contribute to the ongoing discourse on mannitol application. By integrating the latest findings, this review will offer valuable insights into the function of mannitol in decreasing ICP, thereby informing better therapeutic approaches and enhancing patient outcomes.

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