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논문 기본 정보

자료유형
학술저널
저자정보
Seung Wan Hong (Keimyung University School of Medicine Daegu) Yoon Jeong Cho (Catholic University of Daegu School of Medicine Daegu) Jae Hyuck Lee (Keimyung University School of Medicine Daegu) Young Sung Suh (Keimyung University School of Medicine Daegu) Dae Hyun Kim (Keimyung University School of Medicine Daegu)
저널정보
대한임상노인의학회 임상노인의학회지 임상노인의학회지 제24권 제1호
발행연도
2023.4
수록면
24 - 33 (10page)

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Background: Cognitive function is an important issue in aging societies. Testosterone levels and cognitive function are known to be correlated; however, the clinical conclusions remain controversial. This study aimed to investigate whether testosterone supplementation improve cognitive function in adult men through a systematic meta-analysis. Methods: A systematic literature review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. The PubMed, Cochrane Library, and Embase databases were searched. Literature search, study identification, and data extraction were performed between December 2019 and March 2021. Results: A total of 15 studies were included in the meta-analysis. The sample sizes of the selected studies varied from 11 to 493. There were no significant differences in cognitive speed (standardized mean difference [SMD]=−0.05; 95% confidence interval [CI], −0.26 to 0.16), immediate verbal memory function (SMD=0.07; 95% CI, −0.05 to 0.20), immediate visual memory function (SMD=−0.01; 95% CI, −0.15 to 0.13), working memory function (SMD=−0.04; 95% CI, −0.42 to 0.35), delayed memory function (SMD=−0.02; 95% CI, −0.14 to 0.10), executive function (SMD=0.03; 95% CI, −0.08 to 0.15), perception (SMD=−0.13; 95% CI, −0.37 to 0.11), cognitive inhibition (SMD=−0.13; 95% CI, −0.49 to 0.23), visual attention (SMD=−0.02; 95% CI, −0.16 to 0.11), and cognitive status scores (SMD=−0.02; 95% CI, −0.18 to 0.14). Conclusion: The findings of this study indicate that there is a lack of evidence that testosterone administration has an effect on preventing cognitive decline. Therefore, testosterone use to prevent cognitive decline may not be recommended.

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