지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 1 - 9 (9page)
- DOI
- 10.15758/jkak.2017.19.2.1
이용수
초록· 키워드
오류제보하기
[PURPOSE] This study reviewed the current trend of the importance of exercise training-related myokine's function for the prevention of aging. [METHODS] On the basis of searching on the recent research results in pubmed and the other internet research file, we reviewed the recent research output. [RESULTS] Myokine has been regarded an important factor of exercise training and brain growth factor for the prevention of Alzheimier's disease. During exercise the release of anti-inflammatory myokine from contracting skeletal muscle controled the metabolic response, and myostatin, IL-4, IL-6, IL-10, and IL-15 controled skeletal muscle hypertrophy and myogenesis. BDNF and IL-6 promoted the lipid metabolism through AMPK activation. IL-1Ra, IL-10 and sTNF-R inhibited TNF-α as the pro-inflammatory cytokine. IL-15 increased the releasing volume from contracting muscle, and promoted the anabolic factor of muscle growth. IL-7 and IL-8 activated the angiogenesis through the more activation of C-X-C receptor signal transmission. FNDC5/Irisin pathway activated brain cell and BDNF expression through the control of neurogenesis pathway. [CONCLUSIONS] Multiple myokines released from contracting skeletal muscle, and performed the important key factors for skeletal muscle hypertrophy. Therefore exercise training can be suggested the important intervention program for aging prevention and aging-related dysfunction through the delayed sarcopenia. We should try to elucidate the mechanism of myokine's molecular pathway and effects
목차
등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Al-Shanti, N / 2008 / Beneficial synergistic interactions of TNF-alpha and IL-6 in C2skeletal myoblasts–potential cross-talk with IGF system / Growth Factors 26 : 61 ~ 73
Bek, E. L / 2002 / The effect of diabetes on endothelin, interleukin-8 and vascular endothelial growth factor-mediated angiogenesis in rats / Clinical Science (Lond) 103(Suppl 48) : 424S ~ 429S
Bostrὅm, P / 2012 / A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis / Nature 481 : 463 ~ 468
Carbo, N / 2001 / Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control / Biochimica et Biophysica Acta 1526 : 17 ~ 24
Chan, M. H / 2004 / Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability / American Journal of Physiology Regulatory, Integrative and Comparative Physiology 287 : R322 ~ R327
Bek, E. L / 2002 / The effect of diabetes on endothelin, interleukin-8 and vascular endothelial growth factor-mediated angiogenesis in rats / Clinical Science (Lond) 103(Suppl 48) : 424S ~ 429S
Bostrὅm, P / 2012 / A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis / Nature 481 : 463 ~ 468
Carbo, N / 2001 / Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control / Biochimica et Biophysica Acta 1526 : 17 ~ 24
Chan, M. H / 2004 / Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability / American Journal of Physiology Regulatory, Integrative and Comparative Physiology 287 : R322 ~ R327
이 논문의 저자 정보
최근 본 자료
댓글(0)
0