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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 43 - 59 (17page)
- DOI
- 10.15758/jkak.2017.19.2.43
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초록· 키워드
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[PURPOSE] Aging is associated with a progressive loss of skeletal muscle mass and strength as well as physical performance called sarcopenia. Sarcopenia is one of the leading causes of disability in the elderly. Despite the growing prevalence of sarcopenia, the cellular and molecular mechanisms of the aging-related sarcopenia are not fully understood. The purpose of this paper was to review the potential mechanisms of aging-induced sarcopenia and the effects of aerobic and resistance exercise on sarcopenia. [METHODS] A literature review was conducted via web based search engines such as the PUBMED and OVID to collect data and information. [RESULTS] Mitochondria in skeletal muscle may be considered a major factor underlying aging-induced sarcopenia. Alterations in mitochondrial function increase oxidative stress (ROS), interfere with mitochondrial dynamics leading to the unbalance between fusion and fission, impair mitochondrial autophagy (mitophagy), and trigger mitochondrial-mediated apoptosis in aging skeletal muscle. In addition, increased pro-inflammatory cytokines and decreased sex hormones may be associated with aging-induced sarcopenia. [CONCLUSIONS] In this review, we summarize the current knowledge on the potential mechanisms of the aging-related sarcopenia, and highlight the effects of aerobic exercise and resistance exercise on sarcopenia in aging skeletal muscles, suggesting that combined exercise may be the most effective to protect against aging-induced sarcopenia
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참고문헌 (82)
참고문헌 신청
Agergaard, J / 2017 / Light-load resistance exercise increases muscle protein synthesis and hypertrophy signaling in elderly men / American Journal of Physiology-Endocrinology and Metabolism 312(4) : 326 ~ 338
Alway, S. E / 2002 / Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats / American Journal of Physiology-Cell Physiology 283(1) : 66 ~ 76
Behrens, M / 2017 / Modified step aerobics training and neuromuscular function in osteoporotic patients: a randomized controlled pilot study / Archives of Orthopaedic and Trauma Surgery 137(2) : 195 ~ 207
Bori, Z / 2012 / The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle / Experimental Gerontology 47(6) : 417 ~ 424
Braga, M / 2008 / Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice / Apoptosis 13(6) : 822 ~ 832
Alway, S. E / 2002 / Potential role for Id myogenic repressors in apoptosis and attenuation of hypertrophy in muscles of aged rats / American Journal of Physiology-Cell Physiology 283(1) : 66 ~ 76
Behrens, M / 2017 / Modified step aerobics training and neuromuscular function in osteoporotic patients: a randomized controlled pilot study / Archives of Orthopaedic and Trauma Surgery 137(2) : 195 ~ 207
Bori, Z / 2012 / The effects of aging, physical training, and a single bout of exercise on mitochondrial protein expression in human skeletal muscle / Experimental Gerontology 47(6) : 417 ~ 424
Braga, M / 2008 / Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice / Apoptosis 13(6) : 822 ~ 832
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