지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.3
- 수록면
- 15 - 21 (7page)
- DOI
- 10.22889/KJP.2024.55.1.15
이용수
초록· 키워드
오류제보하기
Oxidative stress induced by free radicals formed in the human body crucially contributes to the aging process. Among the compounds with known antioxidant effects, flavonoids are a group of well-known antioxidant phenolic compounds. The ethyl acetate-soluble fraction of the Epimedium koreanum Nakai (Berberidaceae) methanol extract exhibited the potent DPPH radical scavenging activity. From the ethyl acetate fraction, ikarisoside A was isolated by several chromatographic processes. Ikarisoside A was tested for the effects of superoxide dismutase (SOD), catalase, and oxidative stress resistance by using Caenorhabditis elegans along with the active oxygen species (ROS) level. To determine whether the regulation of stress response genes in the ikarisoside A-treated C. elegans was responsible for the increase in stress resistance, SOD-3 expression was measured using transgenic strain CF1553. As a result, the ikarisoside A increased the SOD and catalase activities, reduced the ROS accumulation in a dose-dependent manner, and furthermore, the CF1553 worms treated with the compound exhibited higher SOD-3::GFP intensity compared to control worms.
목차
Abstract
Materials and Methods
Results
Discussion
Conclusions
References
참고문헌 (35)
참고문헌 신청
Yang, S. and Lian, G. (2020) ROS and diseases: role in metabolism and energy supply. Mol. Cell Biochem. 467: 1-12.
Govindan, S., Johnson, E. E. R., Christopher, J., Shanmugam, J., Thirumalairaj, V. and Gopalan, J. (2016) Antioxidant and anti-aging activities of polysaccharides from Calocybe indica var. APK2. Exp. Toxicol. Pathol. 68: 329-334.
Tvrdá, E., Tušimová, E., Kováčik, A., Paál, D., Greifová, H., Abdramanov, A. and Lukáč, N. (2016) Curcumin has protective and antioxidant properties on bull spermatozoa subjected to induced oxidative stress. Anim. Reprod. Sci. 172: 10-20.
Galasso, M., Gambino, S., Romanelli, M. G., Donadelli, M. and Scupoli, M. T. (2021) Browsing the oldest antioxidant enzyme: catalase and its multiple regulation in cancer. Free Radic. Biol. Med. 172: 264-272.
Ahmad, W., Ijaz, B., Shabbiri, K., Ahmed, F. and Rehman, S. (2017) Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/ RNS generation. J. Biomed. Sci. 24: 76.
Govindan, S., Johnson, E. E. R., Christopher, J., Shanmugam, J., Thirumalairaj, V. and Gopalan, J. (2016) Antioxidant and anti-aging activities of polysaccharides from Calocybe indica var. APK2. Exp. Toxicol. Pathol. 68: 329-334.
Tvrdá, E., Tušimová, E., Kováčik, A., Paál, D., Greifová, H., Abdramanov, A. and Lukáč, N. (2016) Curcumin has protective and antioxidant properties on bull spermatozoa subjected to induced oxidative stress. Anim. Reprod. Sci. 172: 10-20.
Galasso, M., Gambino, S., Romanelli, M. G., Donadelli, M. and Scupoli, M. T. (2021) Browsing the oldest antioxidant enzyme: catalase and its multiple regulation in cancer. Free Radic. Biol. Med. 172: 264-272.
Ahmad, W., Ijaz, B., Shabbiri, K., Ahmed, F. and Rehman, S. (2017) Oxidative toxicity in diabetes and Alzheimer's disease: mechanisms behind ROS/ RNS generation. J. Biomed. Sci. 24: 76.
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